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Prognostic nomogram for patients with non-metastatic HER2 positive breast cancer in a prospective cohort
| Content Provider | SAGE Publishing |
|---|---|
| Author | Luo, Chuanxu Zhong, Xiaorong Wang, Zhu Wang, Yu Wang, Yanping He, Ping Peng, Qian Zheng, Hong |
| Copyright Year | 2019 |
| Abstract | A nomogram is a reliable tool to generate individualized risk prediction by combining prognostic factors. We aimed to construct a nomogram for predicting the survival in patients with non-metastatic human epidermal growth factor receptor 2 (HER2) positive breast cancer in a prospective cohort.Methods:We analyzed 1304 consecutive patients who were diagnosed with non-metastatic HER2 positive breast cancer between January 2008 and December 2016 in our institution. Independent prognostic factors were identified to build a nomogram using the COX proportional hazard regression model. The prediction of the nomogram was evaluated by concordance index (C-index), calibration and subgroup analysis. External validation was performed in a cohort of 6379 patients from the Surveillance, Epidemiology, and End Results (SEER) database.Results:Through the COX proportional hazard regression model, five independent prognostic factors were identified. The nomogram predicting overall survival achieved a C-index of 0.78 in the training cohort and 0.74 in the SEER cohort. The calibration plot displayed favorable accordance between the nomogram prediction and the actual observation for 3-year overall survival in both cohorts. The quartiles of the nomogram score classified patients into subgroups with distinct overall survival.Conclusion:We developed and validated a novel nomogram for predicting overall survival in patients with non-metastatic HER2 positive breast cancer, which presented a favorable discrimination ability. This model may assist clinical decision making and patient–clinician communication in clinical practice. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/1724600818824786?download=true |
| Starting Page | 41 |
| Ending Page | 46 |
| Page Count | 6 |
| ISSN | 03936155 |
| Issue Number | 1 |
| Volume Number | 34 |
| Journal | The International Journal of Biological Markers (JBM) |
| e-ISSN | 17246008 |
| DOI | 10.1177/1724600818824786 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2019-03-11 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2019 |
| Subject Keyword | survival Breast cancer HER2 positive nomogram |
| Content Type | Text |
| Resource Type | Article |
| Subject | Clinical Biochemistry Cancer Research Pathology and Forensic Medicine Oncology |
