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Modeling Cell Reactions to Ionizing Radiation: From a Lesion to a Cancer
| Content Provider | SAGE Publishing |
|---|---|
| Author | Dobrzyński, L. Fornalski, K. W. Reszczyńska, J. Janiak, M. K. |
| Copyright Year | 2019 |
| Abstract | This article focuses on the analytic modeling of responses of cells in the body to ionizing radiation. The related mechanisms are consecutively taken into account and discussed. A model of the dose- and time-dependent adaptive response is considered for 2 exposure categories: acute and protracted. In case of the latter exposure, we demonstrate that the response plateaus are expected under the modelling assumptions made. The expected total number of cancer cells as a function of time turns out to be perfectly described by the Gompertz function. The transition from a collection of cancer cells into a tumor is discussed at length. Special emphasis is put on the fact that characterizing the growth of a tumor (ie, the increasing mass and volume), the use of differential equations cannot properly capture the key dynamics—formation of the tumor must exhibit properties of the phase transition, including self-organization and even self-organized criticality. As an example, a manageable percolation-type phase transition approach is used to address this problem. Nevertheless, general theory of tumor emergence is difficult to work out mathematically because experimental observations are limited to the relatively large tumors. Hence, determination of the conditions around the critical point is uncertain. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/1559325819838434?download=true |
| ISSN | 15593258 |
| Issue Number | 2 |
| Volume Number | 17 |
| Journal | Dose-Response (DOS) |
| e-ISSN | 15593258 |
| DOI | 10.1177/1559325819838434 |
| Language | English |
| Publisher | Sage Publications CA |
| Publisher Date | 2019-04-07 |
| Publisher Place | Los Angeles |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2019 |
| Subject Keyword | cancer radiation biophysics physics of cancer ionizing radiation modelling low doses adaptive response |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology Chemical Health and Safety |
