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The Auditory P50 Gating in Mild Cognitive Impairment: A Case-Control Study
| Content Provider | SAGE Publishing |
|---|---|
| Author | Song, Weidong Hu, Xiaohui Xie, Guohua Lai, Wentao Wang, Yang Wu, Donghui |
| Copyright Year | 2022 |
| Abstract | Objective: Auditory P50 gating changed might be a neurophysiological biomarker of the diagnosis of Mild Cognitive Impairment (MCI). We aimed to determine the impact of MCI in auditory P50 gating. Methods: All recruited participants completed structured questionnaires and finished auditory P50 gating measure. Results: A total of 20 MCI patients and 17 controls had been recruited. MCI patients had a significant higher reduction of P50 gating at Fz site, when compared to controls (1.21 ± .68 vs .66 ± .37, P = .00). Zero point five was the best cut off point to distinguish MCI and control of auditory P50 gating S2/S1 at Fz site. The P50 average amplitude at Pz site in MCI patients was significantly higher than controls (2.62 ± 1.20 vs 1.70 ± .74, P = .01). Conclusion: MCI patients might have impaired the ability of inhibiting the repeated stimulus. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/15333175211068966?download=true |
| ISSN | 15333175 |
| Volume Number | 37 |
| Journal | American Journal of Alzheimer's Disease & Other Dementias® (AJA) |
| e-ISSN | 19382731 |
| DOI | 10.1177/15333175211068966 |
| Language | English |
| Publisher | Sage Publications CA |
| Publisher Date | 2022-01-13 |
| Publisher Place | Los Angeles |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2022 |
| Subject Keyword | case-control study auditory event-related potentials P50 gating mild cognitive impairment |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Clinical Psychology Psychiatry and Mental Health Geriatrics and Gerontology |
