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Novel Cancer Stem Marker and Its Applicability for Grading Primary Human Gliomas
| Content Provider | SAGE Publishing |
|---|---|
| Author | Dolgova, Evgeniya V. Mishinov, Sergey V. Proskurina, Anastasiya S. Potter, Ekaterina A. Efremov, Yaroslav R. Bayborodin, Sergey I. Tyrinova, Tamara V. Stupak, Vyacheslav V. Ostatin, Alexandr A. Chernykh, Elena R. Bogachev, Sergey S. |
| Copyright Year | 2018 |
| Abstract | Poorly differentiated cell populations including tumor-initiating stem cells have been demonstrated to display a unique ability to natively internalize fragmented double-stranded DNA. Using this feature as a marker, we show that 0.1% to 6% of human glioblastoma cells from the bioptates can effectively internalize a fluorescently labeled DNA probe. Of these, using samples from 3 patients, 66% to 100% cells are also positive for CD133, a well-established surface marker of tumor-initiating glioma stem cells. Using the samples from primary malignant brain lesions (33 patients), we demonstrate that tumor grading significantly correlates (R = .71) with the percentage of DNA-internalizing cells. No such correlation is observed for relapse samples (18 patients). |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/1533034617753812?download=true |
| ISSN | 15330346 |
| Volume Number | 17 |
| Journal | Technology in Cancer Research & Treatment (TCT) |
| e-ISSN | 15330338 |
| DOI | 10.1177/1533034617753812 |
| Language | English |
| Publisher | Sage Publications CA |
| Publisher Date | 2018-01-28 |
| Publisher Place | Los Angeles |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2018 |
| Subject Keyword | tumor-initiating stem cells CD133 glioblastoma neurosphere TAMRA-DNA |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
