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Surgical Survival Benefits With Different Metastatic Patterns for Stage IV Extrathoracic Metastatic Non-Small Cell Lung Cancer: A SEER-Based Study
| Content Provider | SAGE Publishing |
|---|---|
| Author | Chao, Ce Qian, Yongxiang Li, Xihao Sang, Chen Wang, Bin Zhang, Xiao-ying |
| Copyright Year | 2021 |
| Abstract | With the knowledge of oligometastases, primary surgery plays an increasingly vital role in metastatic non-small cell lung cancer. We aimed to evaluate the survival benefit of primary surgery based on metastatic patterns.Materials and Methods:The selected patients with stage IV extrathoracic metastatic (m1b) non-small cell lung cancer between 2010 and 2015 were included in a retrospective cohort study from the Surveillance, Epidemiology, and End Results (SEER) database. Multiple imputation was used for the missing data. Patients were divided into 2 groups depending on whether surgery was performed. After covariate balancing propensity score (CBPS) weighting, multivariate Cox regression models and Kaplan-Meier survival curve were built to identify the survival benefit of different metastatic patterns.Results:Surgery can potentially increase the overall survival (OS) (adjusted HR: 0.68, P < 0.001) of non-small cell lung cancer. The weighted 3-year OS in the surgical group was 16.9%, compared with 7.8% in the nonsurgical group. For single organ metastasis, surgery could improve the survival of metastatic non-small cell lung cancer. Meanwhile, no significant survival improvements in surgical group were observed in patients with multiple organ metastases.Conclusion:The surgical survival benefits for extrathoracic metastatic non-small cell lung cancer could be divided by metastatic pattern. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/15330338211033064?download=true |
| ISSN | 15330346 |
| Volume Number | 20 |
| Journal | Technology in Cancer Research & Treatment (TCT) |
| e-ISSN | 15330338 |
| DOI | 10.1177/15330338211033064 |
| Language | English |
| Publisher | Sage Publications CA |
| Publisher Date | 2021-09-09 |
| Publisher Place | Los Angeles |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2021 |
| Subject Keyword | non-small cell lung cancer extrathoracic metastases primary surgery metastatic patterns survival benefit |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
