NDLI: Overexpression of MiR-146a-5p Upregulates lncRNA HOTAIR in Triple-Negative Breast Cancer Cells and Predicts Poor Prognosis

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Overexpression of MiR-146a-5p Upregulates lncRNA HOTAIR in Triple-Negative Breast Cancer Cells and Predicts Poor Prognosis

Content Provider	SAGE Publishing
Author	Liang, Hongguang Huang, Weihua Wang, Yuandong Ding, Lingying Zeng, Lixian
Copyright Year	2019
Abstract	MiR-146a-5p plays different roles in different types of cancers. We showed that miR-146a-5p and long noncoding RNA HOTAIR were both upregulated in triple-negative breast cancer. Follow-up study showed that high levels of miR-146a-5p and HOTAIR in tumor tissues were closely correlated with poor survival. MiR-146a-5p and HOTAIR were positively correlated in tumor tissues. MiR-146a-5p positively regulated HOTAIR triple-negative breast cancer cells, while HOTAIR showed no regulatory effects on miR-146a-5p expression. MiR-146a-5p and HOTAIR positively regulated the migration and invasion of triple-negative breast cancer cells. In addition, HOTAIR silencing attenuated the effects of miR-146a-5p. Therefore, overexpression of miR-146a-5p may promote triple-negative breast cancer cell invasion and migration by upregulating HOTAIR.
Related Links	https://journals.sagepub.com/doi/pdf/10.1177/1533033819882949?download=true
ISSN	15330346
Volume Number	18
Journal	Technology in Cancer Research & Treatment (TCT)
e-ISSN	15330338
DOI	10.1177/1533033819882949
Language	English
Publisher	Sage Publications CA
Publisher Date	2019-10-31
Publisher Place	Los Angeles
Access Restriction	Open
Rights Holder	© The Author(s) 2019
Subject Keyword	triple-negative breast cancer miR-146a-5p lncRNA HOTAIR prognosis cancer cell migration
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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