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Coronary flow impairment in asymptomatic patients with early stage type-2 diabetes: Detection by FFRCT
| Content Provider | SAGE Publishing |
|---|---|
| Author | Mrgan, Monija Nørgaard, Bjarne Linde Dey, Damini Gram, Jørgen Olsen, Michael Hecht Gram, Jeppe Niels Peter Rønnow Sand |
| Copyright Year | 2020 |
| Abstract | To determine the occurrence of physiological significant coronary artery disease (CAD) by coronary CT angiography (CTA) derived fractional flow reserve (FFRCT) in asymptomatic patients with a new diagnosis (<1 year) of type-2 diabetes mellitus (T2DM).Methods:FFRCT-analysis was performed from standard acquired coronary CTA data sets. The per-patient minimum distal FFRCT-value (d-FFRCT) in coronary vessels (diameter ⩾1.8 mm) was registered. The threshold for categorizing FFRCT-analysis as abnormal was a d-FFRCT ⩽0.75. Total plaque volume and volumes of calcified plaque, non-calcified plaque, and low-density non-calcified plaque (LD-NCP) were assessed by quantitative plaque analysis.Results:Overall, 76 patients; age, mean (SD): 56 (11) years; males, n (%): 49(65), were studied. A total of 57% of patients had plaques. The d-FFRCT was ⩽0.75 in 12 (16%) patients. The d-FFRCT, median (IQR), was 0.84 (0.79–0.87). Median (range) d-FFRCT in patients with d-FFRCT ⩽0.75 was 0.70 (0.6–0.74). Patients with d-FFRCT⩽0.75 versus d-FFRCT >0.75 had numerically higher plaque volumes for all plaques components, although only significant for the LD-NCP component.Conclusion:Every sixth asymptomatic patient with a new diagnosis of T2DM has hemodynamic significant CAD as evaluated by FFRCT. Flow impairment by FFRCT was associated with coronary plaque characteristics. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/1479164120958422?download=true |
| ISSN | 14791641 |
| Issue Number | 5 |
| Volume Number | 17 |
| Journal | Diabetes and Vascular Disease Research (DVR) |
| e-ISSN | 17528984 |
| DOI | 10.1177/1479164120958422 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2020-09-26 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2020 |
| Subject Keyword | coronary computed tomography angiography derived fractional flow reserve AutoPlaque coronary computed tomography angiography Type-2 diabetes mellitus coronary plaque analysis FFR |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine Cardiology and Cardiovascular Medicine |
