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High myopia is protective against diabetic retinopathy via thinning retinal vein: A report from Fushun Diabetic Retinopathy Cohort Study (FS-DIRECT)
| Content Provider | SAGE Publishing |
|---|---|
| Author | Lin, Zhong Li, Dong Zhai, Gang Wang, Yu Wen, Liang Ding, Xiao Xia Wang, Feng Hua Dou, Yu Xie, Cong Liang, Yuan Bo |
| Copyright Year | 2020 |
| Abstract | To investigate the association between high myopia and diabetic retinopathy, and its possible mechanism, in a northeastern Chinese population with type 2 diabetic mellitus.Methods:Patients were included from Fushun Diabetic Retinopathy Cohort Study. High myopia was defined as spherical equivalent of autorefraction less than −5D.Results:A total of 1817 patients [688 (37.9%) diabetic retinopathy, 102 (5.6%) high myopia] were included. Compared to eyes without high myopia, the frequency of diabetic retinopathy and non-proliferative diabetic retinopathy was significantly less in eyes with high myopia (23.5% vs 38.7%, p = 0.002; 22.5% vs 35.3%, p = 0.005). Eyes with high myopia were less likely to have diabetic retinopathy (multivariate odds ratio, 95% confidence interval: 0.39, 0.22–0.68) or non-proliferative diabetic retinopathy (odds ratio, 95% confidence interval: 0.40, 0.23–0.70). High myopia was negatively associated with central retinal venular equivalent (multivariate β, 95% confidence interval: −37.1, −42.3 to −31.8, p < 0.001). Furthermore, central retinal venular equivalent (per 10 μm increase) had a significant association with diabetic retinopathy (odds ratio, 95% confidence interval: 1.24, 1.17–1.31) as well as non-proliferative diabetic retinopathy (odds ratio, 95% confidence interval: 1.24, 1.18–1.31).Conclusions:High myopia was negatively associated with both diabetic retinopathy and non-proliferative diabetic retinopathy in this northeastern Chinese population. This protective effect may have been partially achieved via thinning retinal veins. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/1479164120940988?download=true |
| ISSN | 14791641 |
| Issue Number | 4 |
| Volume Number | 17 |
| Journal | Diabetes and Vascular Disease Research (DVR) |
| e-ISSN | 17528984 |
| DOI | 10.1177/1479164120940988 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2020-07-18 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2020 |
| Subject Keyword | High myopia diabetic retinopathy central retinal vein |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine Cardiology and Cardiovascular Medicine |
