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A randomised controlled trial evaluating the impact of targeted vitamin D supplementation on endothelial function in type 2 diabetes mellitus: The DIMENSION trial
| Content Provider | SAGE Publishing |
|---|---|
| Author | Dalan, Rinkoo Liew, Huiling Assam, Pryseley Nkouibert Chan, Edwin Sy Siddiqui, Fahad Javaid Tan, Alvin Wk Chew, Daniel Ek Boehm, Bernhard O. Leow, Melvin Ks |
| Copyright Year | 2016 |
| Abstract | We sought to determine if vitamin D supplementation, to target 25(OH)D concentrations of 30–40 ng/mL, improves endothelial function in Singapore’s multi-ethnic type 2 diabetes mellitus population. We randomised 64 type 2 diabetes mellitus patients with hypovitaminosis D to cholecalciferol 4000 International Unit/matching placebo [baseline 25(OH)D < 20 ng/mL] or cholecalciferol 2000 International Unit/matching placebo [baseline 25(OH)D: 20–30 ng/mL] daily for 16 weeks with a down titration at 8 weeks if 25(OH)D > 30 ng/mL. Endothelial function was assessed by peripheral tonometry (reactive hyperaemia index–endothelial peripheral arterial tonometry) and vascular biomarkers: E-selectin, von-Willebrand factor and high-sensitivity C-reactive protein. We compared the change from baseline parameters in the two groups using Student’s t-test or Kruskal–Wallis test. A log-normal multivariate regression analysis was used to adjust for relevant baseline variables. The median reactive hyperaemia index in the vitamin D group increased from 0.65 (interquartile range: 0.42) to 0.73 (interquartile range: 0.36), whereas it decreased from 0.73 (interquartile range: 0.65) to 0.65 (interquartile range: 0.38) (p = 0.02) in the placebo group. After adjustment for baseline variables, the change was not statistically significant for reactive hyperaemia index (p = 0.07) and for other vascular biomarkers (p > 0.05). Targeted vitamin D supplementation for 16 weeks resulted in a small but non-significant improvement in endothelial function in a type 2 diabetes mellitus cohort. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/1479164115621667?download=true |
| Starting Page | 192 |
| Ending Page | 200 |
| Page Count | 9 |
| ISSN | 14791641 |
| Issue Number | 3 |
| Volume Number | 13 |
| Journal | Diabetes and Vascular Disease Research (DVR) |
| e-ISSN | 17528984 |
| DOI | 10.1177/1479164115621667 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2016-01-27 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2016 |
| Subject Keyword | endothelial function Vitamin D cholecalciferol type 2 diabetes |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine Cardiology and Cardiovascular Medicine |
