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Antioxidant effects of a grape seed extract in a rat model of diabetes mellitus
| Content Provider | SAGE Publishing |
|---|---|
| Author | Chis, Irina C. Ungureanu, Marius I. Marton, Adriana Simedrea, Ramona Muresan, Adriana Postescu, Ion-Dan Decea, Nicoleta |
| Abstract | In the present study we investigated the anti-hyperglycaemic and antioxidant effect of grape seed extract, a polyphenolic flavonoid, in normal and streptozotocin-induced diabetic Wistar rats. Adult male Wistar rats were divided into three groups: Group I: non-diabetic control; Group II: diabetic control; Group III: diabetic rats treated with grape seed extract, administered via an intragastric tube (0.6 ml/rat), at a dose of 100 mg/kg for 20 consecutive days after the induction of diabetes mellitus. Diabetes was induced by an i.p. injection with streptozotocin for groups II and III.TheTBARS, carbonylated proteins, were measured in the plasma and in the supernatant of liver homogenisates, and superoxide dismutase and catalase were measured in the haemolysates of RBCs and supernatant of liver homogenisates. The results showed that oral administration of grape seed extract (100 mg/kg/day) reduced the levels of lipid peroxides and carbonylated proteins and improved the antioxidant activity in plasma and hepatic tissue in rats treated with grape seed natural extract as compared with the diabetic control rats. These results suggested that the grape seed extract enhanced the antioxidant defence against reactive oxygen species produced under hyperglycaemic conditions, hence protecting the liver cells. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/1479164109336692?download=true |
| Starting Page | 200 |
| Ending Page | 204 |
| Page Count | 5 |
| ISSN | 14791641 |
| Issue Number | 3 |
| Volume Number | 6 |
| Journal | Diabetes and Vascular Disease Research (DVR) |
| e-ISSN | 17528984 |
| DOI | 10.1177/1479164109336692 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2009-07-30 |
| Publisher Place | London |
| Access Restriction | Open |
| Subject Keyword | Reactive Oxygen Species streptozotocin polyphenols lipid peroxides SOD carbonylated proteins CAT diabetes mellitus |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine Cardiology and Cardiovascular Medicine |
