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Modulation of Innate Defensive Responses by Locus Coeruleus-Superior Colliculus Circuit
| Content Provider | SAGE Publishing |
|---|---|
| Author | Li, Lei Wang, Liping |
| Copyright Year | 2018 |
| Abstract | Among key survival circuits, defensive response circuits are one of the most intensively studied. A consensus is emerging that multiple, independent circuitries are involved in different conditioned and unconditioned defensive responses. Investigating these well-conserved defensive responses would help us to decipher the basic working mechanism of the brain at a circuitry level and thus shed light on new diagnoses and treatments for neural diseases and disorders. We showed that the visually evoked innate defensive response was modulated by a locus coeruleus-superior colliculus (LC-SC) projection. Our work demonstrates that as conserved and instinctive as the survival circuits are, they are flexible and subject to fine-tuned modulation by experience or internal states of the animals. Here, we provide more data to further discuss the possible downstream mechanisms of the LC-SC pathway for this important modulation of the defensive response, the wide range of flight latency between individual flight responses, and the interpretations of our data with additional statistical analysis. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/1179069518792035?download=true |
| ISSN | 26331055 |
| Volume Number | 12 |
| Journal | Journal of Experimental Neuroscience (EXN) |
| e-ISSN | 26331055 |
| DOI | 10.1177/1179069518792035 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2018-08-13 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2018 |
| Subject Keyword | modulation stress superior colliculus norepinephrine defensive circuitry Locus coeruleus looming |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience |
