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Long-term outcomes in Primary congenital glaucoma, aniridia and anterior segment dysgenesis
| Content Provider | SAGE Publishing |
|---|---|
| Author | Magan, Tejal Tanner, Alexander Fajardo-Sanchez, Julia Lim, Kin Sheng Goyal, Saurabh Rodrigues, Ian Amaya, Luis Trikha, Sameer Kulkarni, Avinash Hammond, Christopher Lascaratos, Gerassimos Yu-Wai-Man, Cynthia |
| Copyright Year | 2022 |
| Abstract | AimTo determine the long-term outcomes of a cohort of complex patients with primary congenital glaucoma, aniridia and anterior segment dysgenesis.MethodsRetrospective consecutive series between 1990–2021 in two UK tertiary centres: Guy's and St Thomas’ NHS Foundation Trust and King's College Hospital NHS Foundation Trust. We recorded the number and types of surgical and laser treatments along with preoperative and postoperative data, including intraocular pressures (IOP) and anti-glaucoma medications.ResultsA total of 41 eyes of 21 patients were included. Primary diagnoses were primary congenital glaucoma in 16 eyes (39.0%), aniridia in 14 eyes (34.2%), and anterior segment dysgenesis in 8 eyes (19.5%). Sixteen eyes (39.0%) had one or more glaucoma surgery or laser procedures for advanced glaucoma, and the long-term follow-up was 12.8 ± 3.6 years. There was a significant decrease in postoperative IOP (mmHg) at 3 months (16.5 ± 1.6; p = 0.0067), 6 months (18.7 ± 2.1; p = 0.0386), 12 months (18.6 ± 1.7; p = 0.0229), 3 years (14.7 ± 1.2; p = 0.0126), 5 years (15.5 ± 1.8; p = 0.0330) and 10 years (15.4 ± 2.3; p = 0.7780), compared to preoperatively (24.1 ± 2.6). Surgical success (complete and qualified) was 62.5%, 50.0%, 43.8%, 46.2%, 45.5% and 28.6% at 3 months, 6 months, 12 months, 3 years, 5 years and 10 years, respectively. There was no significant change in the number of anti-glaucoma drugs postoperatively (p > 0.05). Four eyes (25.0%) had postoperative complications (hyphaema, hypotony) that resolved after conservative management.ConclusionsSurgical management of these complex eyes with advanced glaucoma is challenging. Overall, the cohort had good surgical outcomes with a significant decrease in IOP by 36.1% after long-term follow-up. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/11206721211073208?download=true |
| Starting Page | 2920 |
| Ending Page | 2927 |
| Page Count | 8 |
| ISSN | 11206721 |
| Issue Number | 5 |
| Volume Number | 32 |
| Journal | European Journal of Ophthalmology (EJO) |
| e-ISSN | 17246016 |
| DOI | 10.1177/11206721211073208 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2022-01-10 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2022 |
| Subject Keyword | aniridia anterior segment dysgenesis glaucoma surgery Primary congenital glaucoma |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology |
