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Impact of Antithrombin Supplementation and Concomitant Anticoagulation Therapy in Pediatric Patients With Disseminated Intravascular Coagulation
| Content Provider | SAGE Publishing |
|---|---|
| Author | Nagafuchi, Hiroyuki Eguchi, Yutaka Ikeda, Toshiaki |
| Copyright Year | 2019 |
| Abstract | We aimed to evaluate the efficacy and safety of antithrombin (AT) supplementation and concomitant anticoagulation therapy in 65 children who met the Japanese Ministry of Health and Welfare (JMHW) disseminated intravascular coagulation (DIC) criteria and had received AT concentrate and/or other concomitant anticoagulants. The primary efficacy end point was to determine standardized mortality ratio (SMR). The secondary efficacy end points were DIC resolution rate and pediatric sequential organ failure assessment (pSOFA) score on day 3. The 28-day mortality rate was 6.8%; SMR was 0.55. Disseminated intravascular coagulation resolution rate on day 3 was 54.5%. The JMHW DIC scores at day 0 (P = .005) and pSOFA scores at day 3 (P = .018) were significantly lower in patients with resolution of DIC than in those without resolution of DIC. The target cutoff value for JMHW DIC score on day 0 was 6. No bleeding-related adverse events were associated with AT administration. In children with DIC, AT supplementation and concomitant anticoagulation therapy can be safely used as initial treatment when JMHW DIC score is 6; it may improve DIC resolution, organ failure, and mortality rates. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/1076029619834350?download=true |
| ISSN | 10760296 |
| Volume Number | 25 |
| Journal | Clinical and Applied Thrombosis/Hemostasis (CAT) |
| e-ISSN | 19382723 |
| DOI | 10.1177/1076029619834350 |
| Language | English |
| Publisher | Sage Publications CA |
| Publisher Date | 2019-03-06 |
| Publisher Place | Los Angeles |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2019 |
| Subject Keyword | antithrombin disseminated intravascular coagulation JMHW DIC criteria JAAM DIC criteria children |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology |
