Loading...
Please wait, while we are loading the content...
Similar Documents
Circular RNA GLI2 promotes osteosarcoma cell proliferation, migration, and invasion by targeting miR-125b-5p
| Content Provider | SAGE Publishing |
|---|---|
| Author | Li, Ji-Feng Song, Yu-Ze |
| Copyright Year | 2017 |
| Abstract | Circular RNAs are novel identified type of endogenous non-coding RNAs, which exert vital functions in human and animals. However, the in-depth role of circular RNAs in the progression of tumorigenesis, especially osteosarcoma, is still undefined. Our preliminary study had found that cir-GLI2 was significantly upregulated in osteosarcoma tissues compared to adjacent non-tumor tissue. Moreover, cir-GLI2 silencing could effectively suppress the proliferation, migration, and invasion capacity of osteosarcoma cells, indicating the tumor-promoting role. Besides, bioinformatics analysis and luciferase reporter assay predicted the direct binding to miR-125b-5p, which has been reported to function as a tumor suppressor in osteosarcoma. Furthermore, functional experiments validated that cir-GLI2 exerted the tumor-promoting effects on osteosarcoma cells via negatively targeting miR-125b-5p. In conclusion, our study demonstrated that cir-GLI2 acts as an oncogenic circular RNA in osteosarcoma genesis, providing a novel diagnostic and therapeutic target for osteosarcoma. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/1010428317709991?download=true |
| ISSN | 10104283 |
| Issue Number | 7 |
| Volume Number | 39 |
| Journal | Tumor Biology (TUB) |
| e-ISSN | 14230380 |
| DOI | 10.1177/1010428317709991 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2017-07-11 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2017 |
| Subject Keyword | invasion cir-GLI2 miR-125b-5p circular RNAs Osteosarcoma proliferation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Cancer Research |
