NDLI: Long non-coding RNA colon cancer–associated transcript 1 functions as a competing endogenous RNA to regulate cyclin-dependent kinase 1 expression by sponging miR-490-3p in hepatocellular carcinoma progression

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Long non-coding RNA colon cancer–associated transcript 1 functions as a competing endogenous RNA to regulate cyclin-dependent kinase 1 expression by sponging miR-490-3p in hepatocellular carcinoma progression

Content Provider	SAGE Publishing
Author	Dou, Chunqing Sun, Liyuan Jin, Xin Han, Mingming Zhang, Bao Li, Tao
Copyright Year	2017
Abstract	Hepatocellular carcinoma is an aggressive neoplasm and is one of the most common human cancers. Recently, long non-coding RNAs have been demonstrated to participate in pathogenesis of many diseases including the progression in several cancers. In this study, we found that the long non-coding RNA colon cancer–associated transcript 1 was upregulated in hepatocellular carcinoma tissues (p < 0.05), and high colon cancer–associated transcript 1 expression level was positively associated with tumor volume (p < 0.05) and American Joint Committee on Cancer stage (p < 0.05) in hepatocellular carcinoma patients. Luciferase reporter assays and RNA-pulldown assays showed that colon cancer–associated transcript 1 is a target of miR-490-3p. Real-time quantitative polymerase chain reaction and Western blot analysis indicated that colon cancer–associated transcript 1 regulated cyclin-dependent kinase 1 expression as a competing endogenous RNA by sponging miR-490-3p in hepatocellular carcinoma cells. Furthermore, colon cancer–associated transcript 1 silencing decreased hepatocellular carcinoma cells proliferation and invasion and overexpression promoted cell proliferation and invasion in vitro. These data demonstrated that the colon cancer–associated transcript 1/miR-490-3p/cyclin-dependent kinase 1 regulatory pathway promotes the progression of hepatocellular carcinoma. Inhibition of colon cancer–associated transcript 1 expression may be a novel therapeutic strategy for hepatocellular carcinoma.
Related Links	https://journals.sagepub.com/doi/pdf/10.1177/1010428317697572?download=true
ISSN	10104283
Issue Number	4
Volume Number	39
Journal	Tumor Biology (TUB)
e-ISSN	14230380
DOI	10.1177/1010428317697572
Language	English
Publisher	Sage Publications UK
Publisher Date	2017-04-05
Publisher Place	London
Access Restriction	Open
Rights Holder	© The Author(s) 2017
Subject Keyword	Hepatocellular carcinoma competing endogenous RNA miR-490-3p cyclin-dependent kinase 1 colon cancer–associated transcript 1
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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