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Next-generation sequencing revealed synchronous double primary lung squamous carcinoma: a case report
| Content Provider | SAGE Publishing |
|---|---|
| Author | Yang, De-Song Huang, Kai Su, Min Wang, Ting-Ting Liu, Si-Si Xu, Yang Wang, Wen-Xiang |
| Copyright Year | 2021 |
| Abstract | Synchronous double primary lung squamous carcinoma (sDPLSCC) is rare and difficult to distinguish from metastatic disease, histopathologically. Owing to the heterogeneity of cancer, it is also difficult to select the optimal therapeutic strategy for patients with multiple primary lung cancer (MPLC). The present study reports a rare case of a 61-year-old male patient with sDPLSCC diagnosed using histology and genetic profiling. LSCC-related driver mutations were detected in this patient, and we reported the TP53 c.475G>C mutation, which has been detected in both breast cancer and hepatocellular carcinoma, but not previously in lung squamous carcinoma. Our findings provide further evidence supporting the necessity of genetic testing for primary tumor diagnosis. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/03000605211018575?download=true |
| ISSN | 03000605 |
| Issue Number | 5 |
| Volume Number | 49 |
| Journal | Journal of International Medical Research (IMR) |
| e-ISSN | 14732300 |
| DOI | 10.1177/03000605211018575 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2021-05-26 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2021 |
| Subject Keyword | TP53 c.475G>C lung squamous carcinoma genomic profiling Bilateral primary tumor heterogeneity next-generation sequencing (NGS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Cell Biology Biochemistry |
