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Plasma exosomal miR-596: a novel biomarker predicts survival in patients with idiopathic pulmonary artery hypertension
| Content Provider | SAGE Publishing |
|---|---|
| Author | Huang, Yang Wang, Zuo-Gang Tang, Liang Gong, Su-Gang Sun, Yuan-Yuan Wang, Lan Jiang, Rong Wu, Wen-Hui Luo, Ci-Jun Zhang, Jie Yang, Xiao-Jun Li, Jin-Ling Yuan, Xun-Tao Zhao, Qin-Hua Yuan, Ping |
| Copyright Year | 2021 |
| Abstract | ObjectiveTo determine if plasma exosomal microRNAs (miRNAs) can predict survival in patients with idiopathic pulmonary arterial hypertension (IPAH).MethodsThe study enrolled patients with IPAH that underwent right heart catheterization. Plasma was collected and exosomal miRNAs were extracted. Exosomes were evaluated using transmission electron microscopy, Western blot analysis and particle size distribution analysis. MiRNAs were evaluated using a miRNA microarray and validated using real-time polymerase chain reaction.ResultsThis study included 12 patients with IPAH in the study group and 48 patients with IPAH in the validation group. The mean ± SD follow-up duration was 60.3 ± 35.4 months in the overall cohort. The levels of miR-596 were higher in the nonsurvivors compared with the survivors. The levels of miR-596 significantly correlated with survival time, mean right atrial pressure, pulmonary vascular resistance (PVR) and cardiac index. High levels of miR-596 and PVR were significantly associated with poor overall survival. Multivariate analysis demonstrated that exosomal miR-596 (hazard ratio [HR] = 2.119; 95% confidence interval [CI] 1.402, 3.203) and PVR (HR = 1.146; 95% CI 1.010, 1.300) were independent predictors of survival.ConclusionsHigh levels of plasma exosomal miR-596 were significantly associated with disease severity and poor prognosis of patients with IPAH. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/03000605211002379?download=true |
| ISSN | 03000605 |
| Issue Number | 3 |
| Volume Number | 49 |
| Journal | Journal of International Medical Research (IMR) |
| e-ISSN | 14732300 |
| DOI | 10.1177/03000605211002379 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2021-03-31 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2021 |
| Subject Keyword | survival Idiopathic pulmonary arterial hypertension miR-596 exosomal |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Cell Biology Biochemistry |
