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Microstructural damage of normal-appearing white matter in subcortical ischemic vascular dementia is associated with Montreal Cognitive Assessment scores
| Content Provider | SAGE Publishing |
|---|---|
| Author | Liao, Zhangyuan Dang, Chun Li, Meijie Bu, Yali Han, Ranran Jiang, Wei |
| Copyright Year | 2019 |
| Abstract | ObjectivesThis study was performed to determine whether multimodal biomarkers are more strongly associated with the Montreal Cognitive Assessment (MoCA) scores compared with the Mini-Mental State Examination (MMSE) scores, and whether they are correlated with the Clinical Dementia Rating (CDR) in patients with subcortical ischemic vascular dementia (SIVD).MethodsPatients diagnosed with SIVD were enrolled. Peripheral blood hypersensitive C-reactive protein, white matter lesion volume (WMLV), fractional anisotropy (FA)/mean diffusivity (MD) of whole brain white matter (WBWM), and normal-appearing white matter (NAWM) were measured and correlated with MMSE, MoCA, and CDR scores.ResultsBivariate analyses of data from 48 included patients revealed that both MoCA and MMSE were significantly associated with age, education, and FA of NAWM. Only MD of NAWM was correlated with MoCA scores. In partial correlation analysis adjusted for demographic and neuroimaging variables, MD/FA of NAWM and the MoCA scores were significantly correlated. FA/MD of NAWM had a modest trend toward a correlation with the CDR, but it was not significant.ConclusionsIn the patients with SIVD, FA/MD of NAWM were more strongly related to MoCA scores compared with MMSE scores. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/0300060519863520?download=true |
| Starting Page | 5723 |
| Ending Page | 5731 |
| Page Count | 9 |
| ISSN | 03000605 |
| Issue Number | 11 |
| Volume Number | 47 |
| Journal | Journal of International Medical Research (IMR) |
| e-ISSN | 14732300 |
| DOI | 10.1177/0300060519863520 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2019-07-25 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2019 |
| Subject Keyword | diffusion tensor imaging Clinical Dementia Rating cognition multimodal biomarker Cerebral small vessel disease Mini-mental state Examination subcortical ischemic vascular dementia psychological assessment |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Cell Biology Biochemistry |
