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Prompt admission to intensive care is associated with improved survival in patients with severe sepsis and/or septic shock

Content Provider	SAGE Publishing
Author	Li, Qiang Wang, Jiajiong Liu, Guomin Xu, Meng Qin, Yanguo Han, Qin Liu, He Wang, Xiaonan Wang, Zonghan Yang, Kerong Gao, Chaohua Wang, Jin-cheng Zhang, Zhongheng
Copyright Year	2018
Abstract	ObjectiveTo investigate the association between time from hospital admission to intensive care unit (ICU) admission (door to ICU time) and hospital mortality in patients with sepsis.MethodsThis retrospective observational study included routinely collected healthcare data from patients with sepsis. The primary endpoint was hospital mortality, defined as the survival status at hospital discharge. Door to ICU time was calculated and included in a multivariable model to investigate its association with mortality.ResultsData from 13 115 patients were included for analyses, comprising 10 309 survivors and 2 806 non-survivors. Door to ICU time was significantly longer for non-survivors than survivors (median, 43.0 h [interquartile range, 12.4, 91.3] versus 26.7 h [7.0, 74.2]). In the multivariable regression model, door to ICU time remained significantly associated with mortality (odds ratio [OR] 1.11, 95% confidence interval [CI] 1.006, 1.017) and there was a significant interaction between age and door to ICU time (OR 0.99, 95% CI 0.99, 1.00).ConclusionA shorter time from hospital door to ICU admission was shown to be independently associated with reduced hospital mortality in patients with severe sepsis and/or septic shock.
Related Links	https://journals.sagepub.com/doi/pdf/10.1177/0300060518781253?download=true
Starting Page	4071
Ending Page	4081
Page Count	11
ISSN	03000605
Issue Number	10
Volume Number	46
Journal	Journal of International Medical Research (IMR)
e-ISSN	14732300
DOI	10.1177/0300060518781253
Language	English
Publisher	Sage Publications UK
Publisher Date	2018-08-30
Publisher Place	London
Access Restriction	Open
Rights Holder	© The Author(s) 2018
Subject Keyword	Sepsis mortality septic shock
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Cell Biology Biochemistry

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