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Indocyanine green detects sentinel lymph nodes in early breast cancer
| Content Provider | SAGE Publishing |
|---|---|
| Author | Liu, Jun Huang, Linping Wang, Ning Chen, Ping |
| Copyright Year | 2017 |
| Abstract | ObjectiveTo explore the clinical value of indocyanine green (ICG) for the fluorescence-guided detection of sentinel lymph nodes (SLNs) during sentinel lymph node biopsy (SLNB) in patients with early breast cancer.MethodsThis retrospective study included female patients with breast cancer. Patients were administered methylene blue and ICG using standard techniques. All SLNs that were collected during surgery were submitted for pathological examination. SLNs were defined as those that were either fluorescent, blue, fluorescent and blue or palpably suspicious. Surgical complications, axillary recurrence, distant metastasis and overall survival rates were observed postoperatively.ResultsA total of 60 patients were enrolled in the study. The fluorescence detection rate of SLNs was 100% (n = 177), with a mean of 2.95 SLNs per patient. The methylene blue staining rate was 88.3% (n = 106), with a mean of 1.77 SLNs per patient. Pathological assessment of intraoperative frozen specimens revealed SLN metastases in 10 patients, who immediately underwent axillary lymph node dissection. No patient had axillary recurrence or distant metastases, with a survival rate of 100%. Patients who underwent SLNB showed good appearance in the axillary wound, with no limited shoulder joint abduction and upper limb oedema.ConclusionFluorescence-guided SLNB has several advantages and is suitable for clinical application. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/0300060516687149?download=true |
| Starting Page | 514 |
| Ending Page | 524 |
| Page Count | 11 |
| ISSN | 03000605 |
| Issue Number | 2 |
| Volume Number | 45 |
| Journal | Journal of International Medical Research (IMR) |
| e-ISSN | 14732300 |
| DOI | 10.1177/0300060516687149 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2017-03-06 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2017 |
| Subject Keyword | fluorescence imaging Breast cancer indocyanine green sentinel lymph node biopsy (SLNB) methylene blue |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Cell Biology Biochemistry |
