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Asymmetric dimethylarginine and arterial stiffness in patients with rheumatoid arthritis: A case–control study
| Content Provider | SAGE Publishing |
|---|---|
| Author | Erre, Gian Luca Piras, Alessandra Mura, Silvia Mundula, Nicola Piras, Marco Taras, Loredana Longu, Maria Giovanna Saba, Pier Sergio Ganau, Antonello Carru, Ciriaco Passiu, Giuseppe |
| Copyright Year | 2016 |
| Abstract | ObjectiveTo investigate whether levels of asymmetric dimethylarginine (ADMA), as a measure of endothelial dysfunction, are higher in patients with rheumatoid arthritis compared with healthy control subjects. The relationships between ADMA and surrogate measures of arterial stiffness were evaluated.MethodsPatients with rheumatoid arthritis and healthy control subjects were recruited. ADMA was quantified via enzyme-linked immunosorbent assay. Arterial stiffness was evaluated using pulse wave analysis.ResultsThere was no significant difference in plasma ADMA concentration between patients with rheumatoid arthritis (n = 30) and healthy controls (n = 30). Aortic augmentation pressure was significantly higher in patients than in controls. C-reactive protein and Health Assessment Questionnaire score were independent predictors of arterial stiffness in patients. There was no relationship between ADMA concentration and aortic augmentation pressure in the study population as a whole.ConclusionsArterial stiffness appears to be increased in rheumatoid arthritis and independently associated with systemic inflammation and physical disability. ADMA concentration was not increased in this small group of patients with rheumatoid arthritis compared with healthy controls; nor was it associated with arterial stiffness. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/0300060515593255?download=true |
| Starting Page | 76 |
| Ending Page | 80 |
| Page Count | 5 |
| ISSN | 03000605 |
| Issue Number | 1_suppl |
| Volume Number | 44 |
| Journal | Journal of International Medical Research (IMR) |
| e-ISSN | 14732300 |
| DOI | 10.1177/0300060515593255 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2016-09-28 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2016 |
| Subject Keyword | Aortic augmentation pressure endothelial dysfunction arterial stiffness rheumatoid arthritis asymmetric dimethylarginine ADMA |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Cell Biology Biochemistry |
