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Variability of warfarin dose response associated with CYP2C9 and VKORC1 gene polymorphisms in Chinese patients
| Content Provider | SAGE Publishing |
|---|---|
| Author | Ye, Changqing Jin, Haiqiang Zhang, Rui Sun, Yongan Wang, Zhaoxia Sun, Weiping Sun, Wei Peng, Qing Liu, Ran Huang, Yining |
| Copyright Year | 2013 |
| Abstract | ObjectiveTo investigate the prevalence and implication of cytochrome P450, family 2, subfamily C, polypeptide 9 (CYP2C9) variants and vitamin K epoxide reductase complex, subunit 1 (VKORC1)-1639 G > A polymorphisms in Chinese patients receiving warfarin therapy.MethodsChinese Han patients requiring oral warfarin therapy were consecutively enrolled. Correlations between CYP2C9*1, *2, *3, *4, *5 variants and VKORC1-1639 G > A polymorphisms, fourth-day international normalized ratios (INRs) and warfarin maintenance dose were investigated.ResultsOut of 101 patients, there were no significant differences in fourth-day INR or warfarin daily maintenance doses between patients with CYP2C9*1*1 and CYP2C9*1*3 genotypes. Patients with the VKORC1-1639 AA genotype had a higher fourth-day INR (1.87 ± 0.14) than those with the VKORC1-1639 AG genotype (1.32 ± 0.15). Warfarin maintenance dose for patients with the VKORC1-1639 AA genotype (2.40 ± 0.70 mg/day) was significantly lower than for patients with the VKORC1-1639 AG genotype (4.83 ± 0.70 mg/day).ConclusionsUnlike Caucasian populations, VKORC1-1639 G > A polymorphisms in the Chinese population may be the dominant genetic factors associated with warfarin response variability. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/0300060513499094?download=true |
| Starting Page | 67 |
| Ending Page | 76 |
| Page Count | 10 |
| ISSN | 03000605 |
| Issue Number | 1 |
| Volume Number | 42 |
| Journal | Journal of International Medical Research (IMR) |
| e-ISSN | 14732300 |
| DOI | 10.1177/0300060513499094 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2013-11-28 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2013 |
| Subject Keyword | international normalized ratio (INR) polypeptide 9 (CYP2C9) Warfarin subfamily C subunit 1 (VKORC1) vitamin K epoxide reductase complex family 2 single nucleotide polymorphism cytochrome P450 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Cell Biology Biochemistry |
