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Dynamic cerebral autoregulation in Alzheimer’s disease and mild cognitive impairment: A systematic review
| Content Provider | SAGE Publishing |
|---|---|
| Author | Heutz, Rachel Claassen, Jurgen Feiner, Sanne Davies, Aaron Gurung, Dewakar Panerai, Ronney B. Heus, Rianne De Beishon, Lucy C. |
| Copyright Year | 2023 |
| Abstract | Dynamic cerebral autoregulation (dCA) is a key mechanism that regulates cerebral blood flow (CBF) in response to transient changes in blood pressure (BP). Impairment of dCA could increase vulnerability to hypertensive vascular damage, but also to BP lowering effects of antihypertensive treatment. The literature remains conflicted on whether dCA is altered in Alzheimer’s disease (AD) and mild cognitive impairment (MCI). We summarized available data on dCA in AD and MCI, by searching PubMed, Embase, PsycINFO and Web of Science databases (inception-January 2022). Eight studies (total n = 443) were included in the qualitative synthesis of which seven were eligible for meta-analysis. All studies used Transcranial Doppler (TCD) ultrasonography and transfer function analysis or the autoregulatory index to assess dCA during spontaneous or induced BP fluctuations. Meta-analysis indicated no significant difference between AD, MCI and healthy controls in dCA parameters for spontaneous fluctuations. For induced fluctuations, the available data were limited, but indicative of at least preserved and possibly better autoregulatory functioning in AD and MCI compared to controls. In summary, current evidence does not suggest poorer dCA efficiency in AD or MCI. Further work is needed to investigate dCA in dementia with induced fluctuations controlling for changes in end-tidal carbon dioxide. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/0271678X231173449?download=true |
| Starting Page | 1223 |
| Ending Page | 1236 |
| Page Count | 14 |
| ISSN | 0271678X |
| Issue Number | 8 |
| Volume Number | 43 |
| Journal | Journal of Cerebral Blood Flow & Metabolism (JCB) |
| e-ISSN | 15597016 |
| DOI | 10.1177/0271678X231173449 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2023-05-01 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2023 |
| Subject Keyword | cerebral autoregulation mild cognitive impairment dementia Alzheimer’s disease cerebral blood flow |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Neurology (clinical) Cardiology and Cardiovascular Medicine |
