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Maternal myasthenia gravis: A cause for arthrogryposis multiplex congenita
| Content Provider | SAGE Publishing |
|---|---|
| Author | Hoff, Jana Midelfart Midelfart, Anna |
| Copyright Year | 2015 |
| Abstract | Arthrogryposis multiplex congenita (AMC) is a condition defined as contractures in more than two joints and in multiple body areas. The principal mechanism leading to the development of AMC in utero is decreased fetal movement.ObjectiveBoth fetal and maternal factors can lead to this condition, including maternal myasthenia gravis (MG) which is the topic of this review. MG is an autoimmune disease in which antibodies (immunoglobulin G) are formed against acetylcholine receptors. The disease can affect both genders, but women are more prone to develop the disease in early adulthood, a phase of life when the focus of many women is often directed towards founding a family. During pregnancy, maternal antibodies are transmitted to the fetus.ResultsAlthough the child is unaffected in most cases, the constant transmission of antibodies in utero can lead to neonatal myasthenia post-partum, a transient condition characterized by hypotonia and swallowing/respiratory difficulties as well as AMC.ConclusionThe maternal antibody profile in mothers with MG seems to play a key role in whether the child develops AMC or not. There are also indications that there may be a relation between neonatal MG and AMC, as well as a high recurrence rate in siblings. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1007/s11832-015-0690-8?download=true |
| Starting Page | 433 |
| Ending Page | 435 |
| Page Count | 3 |
| ISSN | 18632521 |
| Issue Number | 6 |
| Volume Number | 9 |
| Journal | Journal of Children's Orthopaedics (CHO) |
| e-ISSN | 18632548 |
| DOI | 10.1007/s11832-015-0690-8 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2015-12-01 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © 2015 European Pediatric Orthopaedic Society (EPOS) |
| Rights License | Llicensed Under Creative Commons Licenses |
| Subject Keyword | AMC Myasthenia gravis Neonatal myasthenia gravis Autoimmune disease |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Pediatrics, Perinatology and Child Health |
