NDLI: LncRNA-MALAT1 as a novel biomarker of cadmium toxicity regulates cell proliferation and apoptosis

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Toxicology Research Vol -6

Toxicology Research Vol - 6 Issue - 3

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Outstanding Reviewers for Toxicology Research in 2016

Toxicological implications of mitochondrial localization of CYP2E1

SIRT1 attenuated oxidative stress induced by methyl tert-butyl ether in HT22 cells

Downregulation of catalase by CuO nanoparticles via hypermethylation of CpG island II on the catalase promoter

Identification of a unique gene expression signature in mercury and 2,3,7,8-tetrachlorodibenzo-p-dioxin co-exposed cells

Chromium contributes to human bronchial epithelial cell carcinogenesis by activating Gli2 and inhibiting autophagy

DNA damage in the elderly is associated with 5-MTHF levels: a pro-oxidant activity

Zinc oxide nanoparticle induced age dependent immunotoxicity in BALB/c mice

Nonylphenol induces pancreatic damage in rats through mitochondrial dysfunction and oxidative stress

LncRNA-MALAT1 as a novel biomarker of cadmium toxicity regulates cell proliferation and apoptosis

Assessment of cadmium-induced nephrotoxicity using a kidney-on-a-chip device

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Toxicology Research Vol - 6 Issue - 2

Toxicology Research Vol - 6 Issue - 1

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Toxicology Research Vol -3

Toxicology Research Vol -2

Toxicology Research Vol -1

LncRNA-MALAT1 as a novel biomarker of cadmium toxicity regulates cell proliferation and apoptosis

Content Provider	Royal Society of Chemistry (RSC)
Author	Lei, Yixiong Chen, Baoxin Shen, Huanyu Lu, Qian Huang, Qinhai Liu, Qun Zhou, Zhiheng
Copyright Year	2017
Abstract	Cadmium (Cd) and its compounds are well-known human carcinogens, but the mechanisms underlying the carcinogenesis are not well understood. This study aimed to investigate whether lncRNA-MALAT1 could serve as a novel biomarker of Cd toxicity in cells, animals and Cd-exposed workers, and regulate cell proliferation, apoptosis, migration and invasion. MALAT1 expression increased gradually in CdCl2 transformed 16HBE cells. The cell apoptosis, migration and invasion were significantly inhibited, and the mRNA and protein expression of FOXC2, STAT, BAX, EGFR, and TGF-β1 reduced, but BCL-2 increased (P < 0.05) after silencing MALAT1 by siRNA in CdCl2 treated 16HBE cells of 15th and 35th passages. Cadmium increased MALAT1 expression in the lung of Cd-exposed rats in a dose-dependent manner. A significant positive correlation was observed between blood MALAT1 expression and urinary/blood Cd concentrations, and there were significant correlations of MALAT1 expression with the expressions of target genes in the lung of Cd-exposed rats and the blood of Cd exposed workers. This study suggests that the expression of MALAT1 is upregulated and regulates the cell cycle progression, proliferation, apoptosis, migration and invasion in Cd toxicity. MALAT1 may serve as a novel valuable biomarker of cadmium exposure and cadmium toxicity.
Starting Page	361
Ending Page	371
Page Count	11
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	6
Issue Number	3
Journal	Toxicology Research
DOI	10.1039/c6tx00433d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Bcl-2 Cadmium FOXC2 Biomarker Lung Small interfering RNA Carcinogenesis EGFR Protein Epidermal growth factor receptor Messenger RNA The Cell Cell cycle BAX MALAT1 Apoptosis
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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eIF3 regulates migration, invasion and apoptosis in cadmium transformed 16HBE cells and is a novel biomarker of cadmium exposure in a rat model and in workers

LncRNA-ENST00000446135 is a novel biomarker of cadmium toxicity in 16HBE cells, rats, and Cd-exposed workers and regulates DNA damage and repair.

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LncRNA-MALAT1 regulates proliferation and apoptosis of ovarian cancer cells by targeting miR-503-5p

Ccl21/ccr7 prevents apoptosis via the erk pathway in human non-small cell lung (2011).

Exposure to low dose cadmium enhances FL83B cells proliferation through down-regulation of caspase-8 by DNA hypermethylation

LncRNA-MALAT1 as a novel biomarker of cadmium toxicity regulates cell proliferation and apoptosis

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eIF3 regulates migration, invasion and apoptosis in cadmium transformed 16HBE cells and is a novel biomarker of cadmium exposure in a rat model and in workers

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LncRNA-MALAT1 as a novel biomarker of cadmium toxicity regulates cell proliferation and apoptosis