NDLI: Autophagy as the effector and player in DNA damage response of cells to genotoxicants

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Back cover

Toxicology Research Vol - 4 Issue - 2

Toxicology Research Vol - 4 Issue - 1

Toxicology Research Vol -3

Toxicology Research Vol -2

Toxicology Research Vol -1

Autophagy as the effector and player in DNA damage response of cells to genotoxicants

Content Provider	Royal Society of Chemistry (RSC)
Author	Zhang, Shi-Meng Shang, Zeng-Fu Zhou, Ping-Kun
Copyright Year	2015
Abstract	Autophagy is a highly conserved pathway in eukaryotic cells induced by a variety of stimuli to remove superfluous or damaged organelles or abnormally aggregated proteins to maintain cellular homeostasis. A remarkable progress in our understanding of autophagy has been made in the past decade, not only regarding the molecular mechanism, but also its fundamental roles in the biological effects of various environmental stresses or the development of some human diseases. The genome of eukaryotic cells is constantly threatened by endogenous and exogenous genotoxic factors. Research in recent years has demonstrated that autophagy is not only one of the fundamental effects of genotoxicants but also a critical player in DNA damage response to genotoxic stress. A series of DNA damage response (DDR) proteins including ATM, p53, PARP-1, DNA-PKcs, TIP60, and so on have been demonstrated to play important roles in DNA damage induced autophagy, which functions as a protective measure to promote cell survival. Autophagy was also shown to play roles in the cellular responses to DNA damage, e.g. cell cycle regulation, apoptosis. Although the importance of autophagy in DDR has been recognized, there are still a lot of questions to answer. For example, how does the cell transduce the nuclei DDR signal to the cytosol to initiate autophagy; what is the mechanism of DDR related autophagy determining cell survival or cell death pathway; and what is the mechanism associating the autophagy and carcinogenesis potential of chronic low dose exposure of toxicants? In this review, we provide an overview and discuss the molecular mechanism of DNA damage induced autophagy, and their mutual regulation and its role in cell fate determination in response to genotoxic effects of environmental toxicants.
Starting Page	613
Ending Page	622
Page Count	10
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	4
Issue Number	3
Journal	Toxicology Research
DOI	10.1039/c5tx00043b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	DNA-PKcs PARP1 Genotoxicity Eukaryote Homeostasis Autophagy Cytosol Carcinogenesis Asynchronous Transfer Mode P53 DNA Cell cycle Genome Apoptosis
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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