NDLI: Matrix-derived combination effects influencing absorption, distribution, metabolism and excretion (ADME) of food-borne toxic compounds: implications for risk assessment

Please wait, while we are loading the content...

Matrix-derived combination effects influencing absorption, distribution, metabolism and excretion (ADME) of food-borne toxic compounds: implications for risk assessment

Cellular response to the genotoxic insult: the question of threshold for genotoxic carcinogens

New structural alerts for Ames mutagenicity discovered using emerging pattern mining techniques

Subchronic cyanide toxicity on male reproductive system of albino rat

Elevation of the intracellular Zn²⁺ level by 2-n-octyl-4-isothiazolin-3-one in rat thymocytes: an involvement of a temperature-sensitive Zn²⁺ pathway

N-Ethyl-N-nitrosourea-induced transplacental lung tumor development and its control: molecular modulations for tumor susceptibility in a mouse model

Biocompatibility of graphene oxide intravenously administrated in mice—effects of dose, size and exposure protocols

Application of human cell transformation assay on assessment of carcinogenic potential of river organic pollutants

Failure of pesticides to alter migration of cancerous and non-cancerous breast cell lines in vitro

Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver

Prenatal nicotine exposure-induced intrauterine programming alteration increases the susceptibility of high-fat diet-induced non-alcoholic simple fatty liver in female adult offspring rats

Kinetic and density functional theory (DFT) studies of in vitro reactions of acrylamide with the thiols: captopril, l-cysteine, and glutathione

Palm oil tocotrienol-rich fraction attenuates testicular toxicity induced by fenitrothion via an oxidative stress mechanism

Specific histone modifications regulate the expression of AhR in 16HBE cells exposed to benzo(a)pyrene

An unexpected increase of toxicity of amino acid-containing ionic liquids

Interaction of tannic acid with carbon nanotubes: enhancement of dispersibility and biocompatibility

Label-free monitoring of the nanoparticle surface modification effects on cellular uptake, trafficking and toxicity

Back cover

Toxicology Research Vol -3

Toxicology Research Vol -2

Toxicology Research Vol -1

Matrix-derived combination effects influencing absorption, distribution, metabolism and excretion (ADME) of food-borne toxic compounds: implications for risk assessment

Content Provider	Royal Society of Chemistry (RSC)
Author	Soffers, Ans E. M. F. Punt, Ans Rietjens, Ivonne M. C. M. Berg, Suzanne J. P. L. den Tyrakowska, Bożena
Copyright Year	2015
Abstract	Absorption, distribution, metabolism and excretion (ADME) of food-borne toxic compounds may be influenced by other compounds or constituents present in the food. The present review presents an overview of evidence currently available on food matrix-derived combination effects influencing the ADME characteristics of food-borne toxic compounds and the possible implications for risk assessment. The results obtained indicate that interactions may occur at all levels of ADME and that the interactions may decrease but also increase the bioavailability and/or toxicity of the compounds of interest. The overview also illustrates that food matrix-derived combination effects should be considered on a case-by-case basis, taking into account especially the mode of action underlying the interactions and the dose dependency of the effects. Especially food matrix-derived combination effects that proceed by a reversible mode of action, such as for example binding to biotransformation enzymes or transport proteins, may be detected at concentrations used in in vitro assays and at dose levels used in animal bioassays but may be absent at dose levels representing realistic human intake. It is concluded that although food matrix-derived combination effects may exist, their detection in in vitro assays or in animal bioassays at high dose levels may not improve risk assessment practice because interactions observed may not be maintained at low realistic levels of intake. Insight in the mode of action underlying the interactions combined with physiologically based kinetic (PBK) modelling may prove a way to obtain better insight in whether interactions detected at high dose levels will still be relevant at more realistic lower intake levels, and thus to what extent these effects should be taken into account in the risk assessment for human exposure.
Starting Page	23
Ending Page	35
Page Count	13
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	4
Issue Number	1
Journal	Toxicology Research
DOI	10.1039/c4tx00081a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	ADME Biotransformation PBK Drug metabolism Bioavailability
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Preclinical absorption, distribution, metabolism and excretion (ADME) characterization of ICAM1988, an LFA-1/ICAM antagonist, and its prodrug.

Absorption, distribution, metabolism, and excretion of methylene diphenyl diisocyanate and toluene diisocyanate: Many similarities and few differences

Phenolic compounds: their journey after intake

Absorption, Distribution, Metabolism, and Excretion (ADME) Studies of Biotherapeutics for Autoimmune and Inflammatory Conditions

Computational Methods for the Pharmacogenetic Interpretation of Next Generation Sequencing Data

The Role of Transporters in the Absorption, Distribution, Metabolism and Excretion (ADME) of Orally Administered Drugs

Surfactant effects on skin absorption of model organic chemicals: implications for dermal risk assessment studies.

Absorption, distribution, metabolism and excretion (ADME) study with 2,2',4,4',5,6'-hexabromodiphenyl ether (BDE-154) in male Sprague-Dawley rats.

Preclinical Absorption, Distribution, Metabolism, and Excretion of Sodium Danshensu, One of the Main Water-Soluble Ingredients in Salvia miltiorrhiza, in Rats

Matrix-derived combination effects influencing absorption, distribution, metabolism and excretion (ADME) of food-borne toxic compounds: implications for risk assessment

Similar Documents

Preclinical absorption, distribution, metabolism and excretion (ADME) characterization of ICAM1988, an LFA-1/ICAM antagonist, and its prodrug.

Absorption, distribution, metabolism, and excretion of methylene diphenyl diisocyanate and toluene diisocyanate: Many similarities and few differences

Phenolic compounds: their journey after intake

Absorption, Distribution, Metabolism, and Excretion (ADME) Studies of Biotherapeutics for Autoimmune and Inflammatory Conditions

Computational Methods for the Pharmacogenetic Interpretation of Next Generation Sequencing Data

The Role of Transporters in the Absorption, Distribution, Metabolism and Excretion (ADME) of Orally Administered Drugs

Surfactant effects on skin absorption of model organic chemicals: implications for dermal risk assessment studies.

Absorption, distribution, metabolism and excretion (ADME) study with 2,2',4,4',5,6'-hexabromodiphenyl ether (BDE-154) in male Sprague-Dawley rats.

Preclinical Absorption, Distribution, Metabolism, and Excretion of Sodium Danshensu, One of the Main Water-Soluble Ingredients in Salvia miltiorrhiza, in Rats

Matrix-derived combination effects influencing absorption, distribution, metabolism and excretion (ADME) of food-borne toxic compounds: implications for risk assessment