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Micro-stratified architectures based on successive stacking of alginate gel layers and poly(l-lysine)–hyaluronic acid multilayer films aimed at tissue engineering

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Soft Matter Vol - 4 Issue - 6

Soft Matter Vol - 4 Issue - 5

Soft Matter Vol - 4 Issue - 4

Soft Matter Vol - 4 Issue - 3

Soft Matter Vol - 4 Issue - 2

Soft Matter Vol -3

Soft Matter Vol -2

Soft Matter Vol -0

Micro-stratified architectures based on successive stacking of alginate gel layers and poly(l-lysine)–hyaluronic acid multilayer films aimed at tissue engineering

Content Provider	Royal Society of Chemistry (RSC)
Author	Gillet, Pierre Chassepot, Armelle Decher, Gero Boulmedais, Fouzia Porcel, Claudine Senger, Bernard Benkirane-Jessel, Nadia Netter, Patrick Voegel, Jean-Claude Mjahed, Hajare Schaaf, Pierre
Copyright Year	2008
Abstract	A micro-stratified 3D scaffold was designed by successive stacking of alginate gel layers (AGLs) and poly(L-lysine)–hyaluronic acid (PLL–HA) multilayer films. AGLs are obtained by complexation of alginate by Ca2+ ions. Alginate solutions are first sprayed onto a solid substrate inclined such that the excess of solution be removed by natural drainage. A CaCl2 solution is then either sprayed onto the substrate or the alginate covered substrate is dipped into a CaCl2 solution. The spraying of the CaCl2 solution leads to micro-porous AGLs, whereas the dipping in a CaCl2 aqueous solution leads to a more homogeneous gel layer without porosity. The second process also allows the formation of AGLs with a controlled thickness. With the goal of stacking different AGLs and PLL–HA films, the influence of a PLL–HA precursor film on the formation of AGLs is firstly investigated. It is found that when an alginate solution is sprayed on a PLL–HA multilayer built in the presence of CaCl2, the multilayer plays the role of reservoir of Ca2+ ions and of PLL chains, which both diffuse out of the multilayer film and complex alginate chains. This leads to the formation of a “pre-alginate gel”. When this film is further dipped in the CaCl2 solution, an additional AGL forms, which is, however, free of PLL chains. Finally after the build-up of a PLL–HA film on the top of AGL, we succeeded in designing micro-stratified 3D scaffolds constituted by alternating strata of AGLs and PLL–HA films. This micro-stratified gel provides a new scaffold design with a perfectly controlled build-up: AGL aims to be a 3D scaffold for cell culture, and the PLL–HA multilayers should act as reservoirs for biologically active molecules.
Starting Page	1422
Ending Page	1429
Page Count	8
File Format	HTM / HTML PDF
ISSN	1744683X
Volume Number	4
Issue Number	7
Journal	Soft Matter
DOI	10.1039/b801428k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Cell culture Lysine AGL Alginic acid 3D cell culture Porosity Petroleum reservoir Three-dimensional space
Content Type	Text
Resource Type	Article
Subject	Chemistry Condensed Matter Physics

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Micro-stratified architectures based on successive stacking of alginate gel layers and poly(L-lysine)–hyaluronic acid multilayer films aimed at tissue engineering

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CHO immobilization in alginate/poly-L: -lysine microcapsules: an understanding of potential and limitations.

Multilayer Alginate Microcapsules For Live Cell Microencapsulation; Is There Any Preference For Selecting Cationic Polymers?

Comparison of Linear Poly Ethylene Imine (LPEI) and Poly L-Lysine (PLL) in Fabrication of CHOK1 Cell-Loaded Multilayer Alginate Microcapsules.

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Micro-stratified architectures based on successive stacking of alginate gel layers and poly(l-lysine)–hyaluronic acid multilayer films aimed at tissue engineering

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