NDLI: Probing the adhesion properties of alginate hydrogels: a new approach towards the preparation of soft colloidal probes for direct force measurements

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Soft Matter Vol - 13 Issue - 2

Probing the adhesion properties of alginate hydrogels: a new approach towards the preparation of soft colloidal probes for direct force measurements

Content Provider	Royal Society of Chemistry (RSC)
Author	Bieber, Vera Papastavrou, Georg Lommes, Petra Scheibel, Thomas Helfricht, Nicolas Doblhofer, Elena Sieber, Volker
Copyright Year	2017
Abstract	The adhesion of alginate hydrogels to solid surfaces was probed by atomic force microscopy (AFM) in the sphere/plane geometry. For this purpose a novel approach has been developed for the immobilization of soft colloidal probes onto AFM-cantilevers, which is inspired by techniques originating from cell biology. The aspiration and consecutive manipulation of hydrogel beads by micropipettes allows the entire manipulation sequence to be carried-out in situ. Hence, any alteration of the hydrogel beads upon drying can be excluded. The adhesive behaviour of alginate hydrogels was first evaluated by determining the distribution of pull-off forces on self-assembled monolayers (SAMs) terminating in different functional groups (–CH3, –OH, –NH2, –COOH). It was demonstrated that solvent exclusion plays practically no role in the adhesion process, in clear difference to solid colloidal probes. The adhesion of alginate beads is dominated by chemical interactions rather than solvent exclusion, in particular in the case of amino-terminated SAMs. The data set acquired on the SAMs provided the framework to relate the adhesion of alginate beads on recombinant spider silk protein films to specific functional groups. The preparation of soft colloidal probes and the presented approach in analysing the adhesive behaviour is not limited to alginate hydrogel beads but can be generally applied for probing and understanding the adhesion behaviour of hydrogels on a wide range of substrates, which would be relevant for various applications such as biomedical surface modification or tissue engineering.
Starting Page	578
Ending Page	589
Page Count	12
File Format	HTM / HTML PDF
ISSN	1744683X
Volume Number	13
Issue Number	3
Journal	Soft Matter
DOI	10.1039/c6sm02326f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Euclidean geometry Atomic-force microscopy Spider silk Tissue engineering Alginic acid Spider Molecular biology Pull-off Solvent Protein Gel
Content Type	Text
Resource Type	Article
Subject	Chemistry Condensed Matter Physics

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Pull-off forces measured

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