NDLI: Structure and mechanical response of protein hydrogels reinforced by block copolymer self-assembly

Content Provider	Royal Society of Chemistry (RSC)
Author	Olsen, Bradley D. Glassman, Matthew J.
Copyright Year	2013
Abstract	A strategy for responsively toughening an injectable protein hydrogel has been implemented by incorporating an associative protein as the midblock in triblock copolymers with thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) endblocks, producing materials with a low yield stress necessary for injectability and durability required for load-bearing applications post-injection. Responsive reinforcement triggered by PNIPAM association leads to significant increases in the gel's elastic modulus as well as its resistance to creep. The performance of these materials is a strong function of molecular design, with certain formulations reaching elastic moduli of up to 130 kPa, effectively reinforced by a factor of 14 over their low temperature moduli, and having stress relaxation times increased by up to a factor of 50. The nanostructural origins of these thermoresponsive enhancements were explored, demonstrating that large micellar cores, high PNIPAM volume fractions, and high densities of associating groups in the protein corona lead to the greatest reinforcement of the gel's elastic modulus. Gels with the largest micelles and the highest packing fractions also had the longest relaxation times in the reinforced state. These combined structure and mechanics studies reveal that control of both the micellar and protein networks is critical for making high performance gels relevant for biomedical applications.
Starting Page	6814
Ending Page	6823
Page Count	10
File Format	HTM / HTML PDF
ISSN	1744683X
Volume Number	9
Issue Number	29
Journal	Soft Matter
DOI	10.1039/c3sm00102d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	PNIPAM Elastic modulus Yield (engineering) Poly(N-isopropylacrylamide) Micelle Protein Pascal (unit) Gel Dislocation creep
Content Type	Text
Resource Type	Article
Subject	Chemistry Condensed Matter Physics

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