NDLI: Self-diffusion of water and poly(amidoamine) dendrimers in dilute aqueous solutions

Please wait, while we are loading the content...

Solubilization of polycyclic aromatic hydrocarbons by novel biodegradable cationic gemini surfactant ethane-1,2-diyl bis(N,N-dimethyl-N-hexadecylammoniumacetoxy) dichloride and its binary mixtures with conventional surfactants

A transient polymorph transition of 4-cyano-4′-octyloxybiphenyl (8OCB) revealed by ultrafast differential scanning calorimetry (UFDSC)

Self-assembly of PS-b-P4VP block copolymers of varying architectures in aerosol nanospheres

Highly hydrophobic films with various adhesion by electrodeposition of poly(3,4-bis(alkoxy)thiophene)s

Bridging the gap between microstructure and macroscopic behavior of monodisperse and bimodal colloidal suspensions

Polydicyclopentadiene aerogels grafted with PMMA: I. Molecular and interparticle crosslinking

Polydicyclopentadiene aerogels grafted with PMMA: II. Nanoscopic characterization and origin of macroscopic deformation

Micro- and nanophase separations in hierarchical self-assembly of strongly amphiphilic block copolymer-based ionic supramolecules

Chemical-gradient directed self-assembly of hydrogel fibers

Relaxation characteristics of a compliant microfluidic channel under electroosmotic flow

Monitoring degradation of matrix metalloproteinases-cleavable PEG hydrogels via multiple particle tracking microrheology

The structure and mechanics of nanofibrillar cellulose foams

Nanoparticle formation from hybrid, multiblock copolymers of poly(acrylic acid) and a VPGVG peptide

Intra- and inter-molecular dynamics in glass-forming liquids

Dynamic arrest in model porous media—intermediate scattering functions

Directing enzymatic cross-linking activity to the air–water interface by a fusion protein approach

Bioinspired micro/nanostructured surfaces for oil drag reduction in closed channel flow

A glucose-responsive complex polymeric micelle enabling repeated on–off release and insulin protection

Self-diffusion of water and poly(amidoamine) dendrimers in dilute aqueous solutions

Gelation of the genome by topoisomerase II targeting anticancer agents

The role of the electrostatic double layer interactions in the formation of nanoparticle ring-like deposits at driven receding contact lines

Influence of the mesogenic shape on the molecular dynamics and phase-biaxiality of liquid crystal main-chain polymers

Synthesis and unusual volume phase transition behavior of poly(N-isopropylacrylamide)–poly(2-hydroxyethyl methacrylate) interpenetrating polymer network microgel

Kinetics of aggregation in micellar solutions of thermoresponsive triblock copolymers – influence of concentration, start and target temperatures

Membrane insertion of sliding anchored polymers

Elastocapillary self-folding: buckling, wrinkling, and collapse of floating filaments

Self-diffusion of water and poly(amidoamine) dendrimers in dilute aqueous solutions

Content Provider	Royal Society of Chemistry (RSC)
Author	Nagy, Zoltán Berka, Márta Balogh, Lajos P. Kéri, Mónika Bányai, István
Copyright Year	2013
Abstract	Medium generation PAMAM dendrimers are extensively researched as drug delivery vehicles therefore detailed knowledge of their physico-chemical properties in solution is vital. We have selected ethylenediamine core, generation five poly(amidoamine) (PAMAM_E5) dendrimers (amine terminated PAMAM_E5.NH2 and its succinamic acid derivative PAMAM_E5.SAH, respectively) as model compounds to study their dynamic behavior in water as a function of pH and concentration. Diffusion coefficients of water and the dendrimers were determined in deuterium oxide using pulse-field gradient stimulated echo (PGSE) NMR. The diffusion rate for PAMAM_E5.NH2 increased monotonously with increasing pH values while for PAMAM_E5.SAH a maximum was found at an isoelectric value of pH = 5.7. The apparent diffusion coefficients of dendrimers decreased linearly with increasing concentration measured at their self-pH (pH = 9.4 for PAMAM_E5.NH2 and pH = 5.7 for PAMAM_E5.SAH) in the absence of added salts. The observations could be explained by considering hard sphere interactions between strongly hydrated dendrimer molecules. The average hydrodynamic radii of dendrimers were determined by extrapolating the measured diffusion coefficients to zero dendrimer concentration and applying the Stokes–Einstein equation. The calculated values were RH = 3.05 ± 0.04 nm for PAMAM_E5.NH2 and RH = 3.37 ± 0.08 nm for PAMAM_E5.SAH respectively. Measured diffusion coefficients of water (D2O) also decreased linearly with increasing dendrimer concentration. From the concentration dependence, the average number of water molecules that form one dynamic unit with one macromolecule could be calculated on the basis of three different obstruction models. It has been concluded that hydrated PAMAM dendrimers in aqueous solutions behave as soft colloids against solvent molecules but as hard-sphere colloids against each other. Their equivalent hard-sphere radii were found to be equal to the measured hydrodynamic radii.
Starting Page	1645
Ending Page	1655
Page Count	11
File Format	HTM / HTML PDF
ISSN	1744683X
Volume Number	9
Issue Number	5
Journal	Soft Matter
DOI	10.1039/c2sm26726h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Einstein Dendrimer Hydrodynamic radius Einstein relation (kinetic theory) Drug delivery The Observations Ethylenediamine Heavy water Stokes Macromolecule Poly(amidoamine) Nuclear magnetic resonance Diffusion Correlation and dependence Solvent
Content Type	Text
Resource Type	Article
Subject	Chemistry Condensed Matter Physics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Fourier-transform nuclear magnetic resonance measurements of self-diffusion in the 1,1,2,2-tetrabromoethane + n-alkylbenzene system. Comment on approximate hydrodynamic models for the interpretation of diffusion data

Diffusion and relaxation time of polymers in dilute solutions

Determination of the effective hydrodynamic radii of small molecules by viscometry.

Antibacterial effect of TiO2 modified with poly-amidoamine dendrimer – G3 on S. aureus and E. coli in aqueous solutions

Poly(amidoamine) Dendrimers Increase Antifungal Activity of Clotrimazole

Dendritic Chelating Agents . 2 . U ( VI ) Binding to Poly ( amidoamine ) and Poly ( propyleneimine ) Dendrimers in Aqueous Solutions

Transferrin Conjugated pH- and Redox-Responsive Poly(Amidoamine) Dendrimer Conjugate as an Efficient Drug Delivery Carrier for Cancer Therapy

Investigation of nickel removal using poly(amidoamine) generation 4 dendrimer (PAMAM G4) from aqueous solutions

Organocatalysis by poly(amidoamine) dendrimers; Knoevenagel and Mannich reactions catalyzed in water

Self-diffusion of water and poly(amidoamine) dendrimers in dilute aqueous solutions

Similar Documents

Fourier-transform nuclear magnetic resonance measurements of self-diffusion in the 1,1,2,2-tetrabromoethane + n-alkylbenzene system. Comment on approximate hydrodynamic models for the interpretation of diffusion data

Diffusion and relaxation time of polymers in dilute solutions

Determination of the effective hydrodynamic radii of small molecules by viscometry.

Antibacterial effect of TiO2 modified with poly-amidoamine dendrimer – G3 on S. aureus and E. coli in aqueous solutions

Poly(amidoamine) Dendrimers Increase Antifungal Activity of Clotrimazole

Dendritic Chelating Agents . 2 . U ( VI ) Binding to Poly ( amidoamine ) and Poly ( propyleneimine ) Dendrimers in Aqueous Solutions

Transferrin Conjugated pH- and Redox-Responsive Poly(Amidoamine) Dendrimer Conjugate as an Efficient Drug Delivery Carrier for Cancer Therapy

Investigation of nickel removal using poly(amidoamine) generation 4 dendrimer (PAMAM G4) from aqueous solutions

Organocatalysis by poly(amidoamine) dendrimers; Knoevenagel and Mannich reactions catalyzed in water

Self-diffusion of water and poly(amidoamine) dendrimers in dilute aqueous solutions