NDLI: Self-organization of amide dendrons with focal dipeptide units

Content Provider	Royal Society of Chemistry (RSC)
Author	Park, Junwon Kim, Joung Min Yun, Mikyoung Park, Chiyoung Kim, Chulhee Lee, Jeonghun Lee, Keun Hyeung
Copyright Year	2011
Abstract	Dendron–dipeptide conjugates were synthesized to investigate their self-assembly characteristics not only in the aqueous phase but also in organic media. In the aqueous phase, the self-organized structure of 2G-PhePhe and 2G-GlyGly was influenced predominantly by the self-assembly characteristics of the amide dendron unit to exhibit vesicular structures. For 1G-PhePhe and 1G-GlyGly, however, the role of the focal dipeptide unit became important to show donut-like assemblies and rod-like structures, respectively. In HFIP/H2O (1 : 100 v/v), 2G-PhePhe and 1G-PhePhe exhibited donut-like structures, while 2G-GlyGly and 1G-GlyGly formed rod-like structures. The secondary structures of the dendron–peptide conjugates were remarkably influenced by the dendron unit. The circular dichroism (CD) spectra showed that 1G-PhePhe in H2O adopted the β-sheet structure. On increasing the generation of the dendron unit, on the other hand, 2G-PhePhe did not adopt the β-sheet structure but exhibited random structures. In addition, the curvature of the assembled structure of the dendron–peptide conjugates was affected by the dendron unit. In organic media such as toluene, all the dendron–dipeptide conjugates formed fibrous structures which could induce thermoreversible gel formation. Therefore, the modulation of the dendritic moiety and the focal peptide unit provided an opportunity to produce diverse self-organized structures in various conditions.
Starting Page	9021
Ending Page	9026
Page Count	6
File Format	HTM / HTML PDF
ISSN	1744683X
Volume Number	7
Issue Number	19
Journal	Soft Matter
DOI	10.1039/c1sm06008b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Dipeptide Self-assembly Properties of water Toluene Amide Beta sheet Curvature Peptide Circular dichroism
Content Type	Text
Resource Type	Article
Subject	Chemistry Condensed Matter Physics

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