NDLI: Selectivity engineering of the diazotization reaction in a continuous flow reactor

Please wait, while we are loading the content...

Continuous flow synthesis concatenated with continuous flow liquid–liquid extraction for work-up and purification: selective mono- and di-iodination of the imidazole backbone

Hydrogenation of 2-methyl-3-butyn-2-ol over a Pd/ZnO catalyst: kinetic model and selectivity study

Structuring hybrid palladium nanoparticles in metallic monolithic reactors for continuous-flow three-phase alkyne hydrogenation

Back cover

Reaction Chemistry & Engineering Vol - 1 Issue - 3

Reaction Chemistry & Engineering Vol - 1 Issue - 2

Reaction Chemistry & Engineering Vol - 1 Issue - 1

Selectivity engineering of the diazotization reaction in a continuous flow reactor

Content Provider	Royal Society of Chemistry (RSC)
Author	Kulkarni, A. A. Ranade, V. V. Shukla, C. A.
Copyright Year	2016
Abstract	In situ generated diazonium salts are useful intermediates for the synthesis of fine chemicals and active pharmaceutical ingredients. This paper presents a methodology for selectivity engineering of the diazotization reaction in a continuous reactor. The yield of diazotization was found to depend on mixing, dispersion, reaction kinetics, operating temperature and residence time. Initially, experimental data and an isothermal axial dispersion model were used for estimating mixing time. A correlation for estimating mixing time for different flow reactors is proposed. The model predictions were compared with the experimental data. The validated axial dispersion model and Central Composite Design (CCD) were used to optimize diazotization in a straight tube reactor (1.78 mL). The model was then used for scaling-up of aniline diazotization from a straight tube reactor to a proprietary AmAR3 reactor (scale-up ratio of ∼20). The initial concentration, inlet temperature, average heat capacity of the reaction mixture, mixing, residence time (distribution) and available heat transfer area per unit volume of the reactor were found to be the key parameters for scaling-up of the diazotization reaction. The presented approach and results will be useful to practicing chemists and engineers for enhancing the selectivity of diazotization reactions in continuous reactors.
Starting Page	387
Ending Page	396
Page Count	10
File Format	HTM / HTML PDF
ISSN	20589883
Volume Number	1
Issue Number	4
Journal	Reaction Chemistry & Engineering
DOI	10.1039/c5re00056d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Statistical dispersion Isothermal process Charge-coupled device Diazonium compound Aniline Heat capacity Heat transfer Operating temperature
Content Type	Text
Resource Type	Article
Subject	Chemistry Fluid Flow and Transfer Processes Catalysis Process Chemistry and Technology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process

Kinetics of nanocrystal synthesis in a microfluidic reactor: theory and experiment

Online monitoring and analysis for autonomous continuous flow self-optimizing reactor systems

A miniature CSTR cascade for continuous flow of reactions containing solids

Reaction Chemistry & Engineering

Continuous flow Buchwald–Hartwig amination of a pharmaceutical intermediate

Design, Modelling, and Experimental Validation of a Scalable Continuous-Flow Hydrothermal Liqtion Pilot Plant

A reactive continuous chromatographic process for protein PEGylation

Continuous photochemistry: the flow synthesis of ibuprofen via a photo-Favorskii rearrangement

Selectivity engineering of the diazotization reaction in a continuous flow reactor

Similar Documents

A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process

Kinetics of nanocrystal synthesis in a microfluidic reactor: theory and experiment

Online monitoring and analysis for autonomous continuous flow self-optimizing reactor systems

A miniature CSTR cascade for continuous flow of reactions containing solids

Reaction Chemistry & Engineering

Continuous flow Buchwald–Hartwig amination of a pharmaceutical intermediate

Design, Modelling, and Experimental Validation of a Scalable Continuous-Flow Hydrothermal Liqtion Pilot Plant

A reactive continuous chromatographic process for protein PEGylation

Continuous photochemistry: the flow synthesis of ibuprofen via a photo-Favorskii rearrangement

Selectivity engineering of the diazotization reaction in a continuous flow reactor