NDLI: Evaluation of the anti-cancer activity of the triterpenoidal saponin fraction isolated from the traditional Chinese medicine Conyza blinii H. Lév.

Content Provider	Royal Society of Chemistry (RSC)
Author	Zhang, Botao Qin, Ping Ma, Long Meng, Lingpei Li, Yuyin Liu, Haiyan Man, Shuli Liu, Zhenxing Liu, Zhen Diao, Aipo
Copyright Year	2017
Abstract	Conyza blinii H. Lév. is traditionally used in China as a medicinal plant to treat inflammation. We show here that the active fraction of this plant, Conyza blinii saponin (CBS), also has potent anti-cancer activity both in vitro and in vivo. Cell-based experiments showed that CBS suppresses the growth of cancer cells in a number of ways. CBS induces apoptosis in a dose-dependent manner. The mitochondrial membrane potential (ΔΨm) can be disrupted by CBS, which indicates activation of the mitochondrial apoptosis pathway. This was confirmed by an increase in the number of apoptotic bodies seen with scanning electron microscopy. CBS is capable of inhibiting cancer cell migration and invasion. Flow cytometry experiments demonstrated that CBS causes S phase arrest in cancer cells. These effects collectively led to an inhibitory activity against HeLa cells. In vivo animal experiments were carried and showed that 15 mg kg−1 CBS is a tolerable dose and reduced the tumour weight by 70% in a 10 day administration regimen.
Starting Page	3408
Ending Page	3412
Page Count	5
File Format	HTM / HTML PDF
ISSN	20462069
Volume Number	7
Issue Number	6
Journal	RSC Advances
DOI	10.1039/c6ra26361e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Flow cytometry Inflammation Herbalism Scanning electron microscope Saponin HeLa CBS S phase China Membrane potential Cancer Apoptosis
Content Type	Text
Resource Type	Article
Subject	Chemistry Chemical Engineering

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