NDLI: Synthesis and characterization of photodynamic activity of an iodinated Chlorin p<sub>6</sub> copper complex

Content Provider	Royal Society of Chemistry (RSC)
Author	Sarbadhikary, Paromita Gupta, Pradeep Kumar Dube, Alok
Copyright Year	2016
Abstract	We report the synthesis of a new iodinated Chlorin p6 copper complex (ICp6–Cu) and its efficacy for photodynamic treatment (PDT) of cancer cells. The metal complex is obtained by reacting Chlorin p6 (Cp6) with copper iodide (CuI). The complex formation results in a shift in the Q absorption band of Cp6 from 663 nm to 634 nm and X-ray fluorescence of the complex showed the presence of both copper and iodine. FTIR and EPR spectroscopy suggests that the copper is attached to Cp6 at the two adjacent carboxylic groups. Studies on the photochemical generation of singlet oxygen (1O2) and other reactive oxygen species (ROS) using fluorescence probes revealed that ICp6–Cu acts predominantly through the type I process. PDT of oral cancer cells with ICp6–Cu (10 μM, 3 h) and red light (630 ± 20 nm, ∼12 J cm−2) led to ∼90% phototoxicity. Furthermore, in contrast to Cp6, the phototoxicity induced by ICp6–Cu is not significantly affected under hypoxic conditions.
Starting Page	75782
Ending Page	75792
Page Count	11
File Format	HTM / HTML PDF
ISSN	20462069
Volume Number	6
Issue Number	79
Journal	RSC Advances
DOI	10.1039/c6ra14026b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Reactive oxygen species Photodynamic therapy Oral cancer EPR Fluorescence Chlorin X-ray fluorescence Singlet oxygen FTIR Absorption band Phototoxicity Copper(I) iodide Electron paramagnetic resonance Copper Cancer Iodine Photochemistry
Content Type	Text
Resource Type	Article
Subject	Chemistry Chemical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Enhancement of radiosensitivity of oral carcinoma cells by iodinated chlorin p6 copper complex in combination with synchrotron X-ray radiation.

Singlet oxygen generation using iodinated squaraine and squaraine-rotaxane dyesw (2006).

Cytotoxicity of InP/ZnS quantum dots related to reactive oxygen species generation

The hydroxypyridinone iron chelator CP94 increases methyl-aminolevulinate-based photodynamic cell killing by increasing the generation of reactive oxygen species

Potassium Iodide Potentiates Broad-Spectrum Antimicrobial Photodynamic Inactivation Using Photofrin

Photochemistry of hypocrellin derivatives under aerobic conditions

Reactive oxygen species formation at Pt nanoparticles revisited by electron paramagnetic resonance and electrochemical analysis

Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

Optical and epr studies on the 5 ev band (1971).

Synthesis and characterization of photodynamic activity of an iodinated Chlorin p₆ copper complex

Similar Documents

Enhancement of radiosensitivity of oral carcinoma cells by iodinated chlorin p6 copper complex in combination with synchrotron X-ray radiation.

Singlet oxygen generation using iodinated squaraine and squaraine-rotaxane dyesw (2006).

Cytotoxicity of InP/ZnS quantum dots related to reactive oxygen species generation

The hydroxypyridinone iron chelator CP94 increases methyl-aminolevulinate-based photodynamic cell killing by increasing the generation of reactive oxygen species

Potassium Iodide Potentiates Broad-Spectrum Antimicrobial Photodynamic Inactivation Using Photofrin

Photochemistry of hypocrellin derivatives under aerobic conditions

Reactive oxygen species formation at Pt nanoparticles revisited by electron paramagnetic resonance and electrochemical analysis

Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

Optical and epr studies on the 5 ev band (1971).

Synthesis and characterization of photodynamic activity of an iodinated Chlorin p6 copper complex

Synthesis and characterization of photodynamic activity of an iodinated Chlorin p₆ copper complex