NDLI: The effect of Tookad-mediated photodynamic ablation of the prostate gland on adjacent tissues

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Photochemical & Photobiological Sciences Vol - 6 Issue - 9

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The effect of Tookad-mediated photodynamic ablation of the prostate gland on adjacent tissues—in vivo study in a canine model

Content Provider	Royal Society of Chemistry (RSC)
Author	Wilson, Brian C. Chen, Qun Dole, Kenneth C. Chen, Yang K. Hetzel, Fred W. Blanc, Dominique Barqawi, Al B. Huang, Zheng
Copyright Year	2007
Abstract	Photodynamic therapy (PDT) mediated with vascular acting photosensitizer Tookad (Pd-bacteriopheophorbide) was investigated as an alternative modality for treating prostate cancer. Photodynamic effects on the prostate gland and its adjacent tissues were evaluated in a canine model. Interstitial prostate PDT was performed by irradiating individual lobes with a cylindrical diffuser fiber at various drug/light doses. The sensitivity of the adjacent tissues to Tookad PDT was determined by directly irradiating the surface of the bladder, colon, abdominal muscle and pelvic plexus with a microlens fiber at various drug/light doses. The prostate and adjacent tissues were harvested one-week after the treatment and subjected to histopathological examination. PDT-induced prostate lesions were characterized by marked hemorrhagic necrosis. The bladder, colon, abdominal muscle and pelvic plexus appeared to be sensitive to PDT although the Tookad PDT-induced responses in these tissues were minimal compared to that of the prostate gland at the same dose levels. Nevertheless, the protection of the adjacent tissues should be taken into consideration during the total prostate ablation process due to their sensitivity to PDT. The sensitivity of the prostatic urethra is worth further investigation. Direct intraurethral irradiation might provide an ideal means to determine the sensitivity of the prostatic urethra and might lead to transurethral PDT protocols for the management of benign prostatic hyperplasia (BHP).
Starting Page	1318
Ending Page	1324
Page Count	7
File Format	HTM / HTML PDF
ISSN	1474905X
Volume Number	6
Issue Number	12
Journal	Photochemical & Photobiological Sciences
DOI	10.1039/b705984a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	Inferior hypogastric plexus Photodynamic therapy Prostatic urethra Ablation Necrosis Microlens Large intestine Horsepower Benign prostatic hyperplasia Tookad Photosensitizer Prostate cancer Prostate
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry

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The effect of Tookad-mediated photodynamic ablation of the prostate gland on adjacent tissues - in vivo study in a canine model

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