NDLI: Redistribution of Foscan® from plasma proteins to model membranes

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Effects of cadmium and enhanced UV radiation on the physiology and the concentration of UV-absorbing compounds of the aquatic liverwort Jungermannia exsertifolia subsp. cordifolia

Redistribution of Foscan® from plasma proteins to model membranes

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Photochemical & Photobiological Sciences Vol - 5 Issue - 7

Photochemical & Photobiological Sciences Vol - 5 Issue - 6

Photochemical & Photobiological Sciences Vol - 5 Issue - 5

Photochemical & Photobiological Sciences Vol - 5 Issue - 4

Photochemical & Photobiological Sciences Vol - 5 Issue - 3

Photochemical & Photobiological Sciences Vol - 5 Issue - 2

Photochemical & Photobiological Sciences Vol -4

Photochemical & Photobiological Sciences Vol -3

Photochemical & Photobiological Sciences Vol -2

Redistribution of Foscan® from plasma proteins to model membranes

Content Provider	Royal Society of Chemistry (RSC)
Author	Sasnouski, Siarhei Guillemin, François Kachatkou, Dzmitry Zorin, Vladimir Bezdetnaya, Lina
Copyright Year	2006
Abstract	Photodynamic therapy is a comparatively novel modality of tumours treatment that includes simultaneous action of photosensitizers, light and oxygen. Photosensitizer redistribution between plasma proteins and biomembranes define photosensitizers interaction with cells, their intracellular localization and kinetics of sensitizers accumulation in the tumour. Present study investigates the kinetics of Foscan® release from plasma proteins to model membranes using fluorescence resonance energy transfer (FRET) from label, covalently bound to protein, to sensitizer. We have demonstrated very slow kinetics of Foscan® release from protein complexes with rate constants of (1.7 ± 0.1) × 10−3 s−1 for albumin and (1.6 ± 0.3) × 10−4 s−1 for high-density lipoproteins (HDL). Foscan® redistributes by both collision and diffusion-mediated transfer from complexes with HDL, with bimolecular rate constant kout = (8.8 ± 1.4) × 10−2 M−1 s−1. Thermodynamic considerations proposed that sensitizer release from HDL into the aqueous medium is unfavourable and collision mechanism appeared to be a preferred mode of transfer in biological environment. Slow rates of Foscan® redistribution from plasma proteins should be considered while planning dosimetry protocol of Foscan®-PDT.
Starting Page	770
Ending Page	777
Page Count	8
File Format	HTM / HTML PDF
ISSN	1474905X
Volume Number	5
Issue Number	8
Journal	Photochemical & Photobiological Sciences
DOI	10.1039/b603840a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Subscribed
Subject Keyword	KOUT Förster resonance energy transfer Speed Oxygen Photodynamic therapy Fluorescence Albumin Protein Blood plasma High-density lipoprotein Temoporfin Dosimetry Photosensitizer
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry

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