NDLI: Spectroscopic study on the binding of a cationic porphyrin to DNA G-quadruplex under different K<sup>+</sup> concentrations

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Spectroscopic study on the binding of a cationic porphyrin to DNA G-quadruplex under different K⁺ concentrations

Content Provider	Royal Society of Chemistry (RSC)
Author	Wang, Peng Zhang, Hui-Juan Wang, Xue-Fei Ai, Xi-Cheng Zhang, Jian-Ping
Copyright Year	2008
Abstract	We have performed systematic spectroscopic titrations to characterize the binding reaction of cationic meso-tetrakis(4-(N-methylpyridiumyl))porphyrin (TMPyP4) with the G-quadruplex (G4) of human telomeric single-strand oligonucleotide d[TAGGG(TTAGGG)3T] (S24), for which special effort was made to examine the TMPyP4-G4 binding stoichiometry, the binding modes, and the conformational conversion of the G4 structure under different potassium ion (K+) concentration. It is found that, in the presence of 0, 10 mM, and 100 mM K+, TMPyP4 forms a complex with the anti-parallel G4 in a TMPyP4-to-G4 molar ratio of 5, 5 and 3, respectively, and the increase of K+ concentration would reduce the binding affinity of TMPyP4 to G4. For the TMPyP4–G4 complex, the end-stacking mode and groove binding mode were presumed mainly by the results of time-resolved fluorescence spectroscopy in the three cases. Most importantly, it is found that TMPyP4 can directly induce the formation of the anti-parallel G4 structure from the single-strand oligonucleotide S24 in the absence of K+, and that it can preferentially induce the conformational conversion of the G4 structure from the hybrid-type to the anti-parallel one in the presence of K+.
Starting Page	948
Ending Page	955
Page Count	8
File Format	HTM / HTML PDF
ISSN	1474905X
Volume Number	7
Issue Number	8
Journal	Photochemical & Photobiological Sciences
DOI	10.1039/b809322a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Special Effort Stoichiometry Spectroscopy Porphyrin G-quadruplex Fluorescence Ion Oligonucleotide S24 (ZVV) Potassium Molar concentration Power Mac G4
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry

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