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Mechanical and vibrational characterization of amyloid-like HET-s nanosheets based on the skewed plate theory

Content Provider	Royal Society of Chemistry (RSC)
Author	Kim, Jae In Lee, Myeongsang Na, Sungsoo Yoon, Gwonchan Chang, Hyun Joon
Copyright Year	2017
Abstract	Pathological amyloidogenic prion proteins have a toxic effect on functional cells in the human cerebrum because of poor degradability and the tendency to accumulate in an uncontrolled manner under physiological conditions. HET-s, a fungal prion protein, is known to undergo conformational variations from fibrillar to nanosheet structures during a change from low to high pH conditions. It has been said that this conformational change can lead to self-propagation by nucleating on the lateral surface of singlet fibrils. Efforts have been made toward the mechanical characterization of fibrillar amyloids, but a global understanding of amyloid-like HET-s nanosheet structures is lacking. In this study, we analyzed the mechanical and vibrational characteristics of the skewed HET-s nanosheet structures that developed under neutral pH conditions by performing various molecular dynamics simulations. By applying the skewed plate theory to HET-s nanosheets for various length scales with numerous pores inside the structures, we found that the skewed HET-s nanosheet structure has mechanical properties comparable to those of previously reported biological film materials and nanomaterials. Considering the inherent characteristics of structural stability, our observation provides valuable and detailed structural information on skewed amyloid-like HET-s nanosheets.
Starting Page	11492
Ending Page	11501
Page Count	10
File Format	HTM / HTML PDF
ISSN	14639076
Volume Number	19
Issue Number	18
Journal	Physical Chemistry Chemical Physics
DOI	10.1039/c7cp01418j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Nanosheet Fungal prion Cerebrum Molecular dynamics Nanomaterials Prion Protein
Content Type	Text
Resource Type	Article
Subject	Physics and Astronomy Physical and Theoretical Chemistry

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The HET-s prion protein of the filamentous fungus Podospora anserina aggregates in vitro into amyloid-like fibrils (2002)

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