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Preparation and rapid degradation of nontoxic biodegradable polyurethanes based on poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid) and l-lysine diisocyanate

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Back cover

Polymer Chemistry Vol - 2 Issue - 2

Polymer Chemistry Vol -1

Preparation and rapid degradation of nontoxic biodegradable polyurethanes based on poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid) and l-lysine diisocyanate

Content Provider	Royal Society of Chemistry (RSC)
Author	Ding, Mingming Li, Jiehua Wang, Zhigao Yu, Lunquan Tan, Hong Fu, Qiang
Copyright Year	2011
Abstract	To obtain rapid biodegradable biomaterials, a biodegradable triblock oligomer poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid) (PLA-PEG-PLA) was designed and synthesized as a soft segment of polyurethane. Then new nontoxic biodegradable polyurethanes were prepared using the same stoichiometric ratio of PLA-PEG-PLA, L-lysine ethyl ester diisocyanate (LDI), and 1,4-butanediol (BDO). The molecular weights of polyurethanes were controlled by adjusting the polymerization temperature. The resulting polyurethanes were characterized by gel permeation chromatography (GPC), Fourier transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC). Furthermore, the biodegradability of the synthesized polyurethanes was evaluated at 37 °C in phosphate buffer solutions (PBS) under different pH values and enzymatic solution at pH 7.4. The results showed that these polyurethanes could be rapidly degraded in PBS and enzymatic solution, as demonstrated by weight loss measurements and scanning electron microscope (SEM) observations. The degradation rates of these polyurethanes were mainly regulated by microphase separation degree, and could be restrained in lower pH value PBS. Moreover, the degradation products did not significantly decrease the pH value of incubation media, which would be useful to improve biocompatibilities of these polyurethanes in vivo. The current work provides a more promising approach to prepare nontoxic biodegradable polyurethanes with rapid degradation rates. These new materials may find potential use for drug delivery systems and magnetic resonance imaging (MRI) contrast agents.
Starting Page	601
Ending Page	607
Page Count	7
File Format	HTM / HTML PDF
ISSN	17599954
Volume Number	2
Issue Number	3
Journal	Polymer Chemistry
DOI	10.1039/c0py00235f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	PBS Biodegradation Ethylene glycol Stoichiometry Differential scanning calorimetry 1,4-Butanediol Polylactic acid Polymerization Drug delivery Fourier-transform infrared spectroscopy Oligomer Scanning electron microscope Gel permeation chromatography Ester Fourier Magnetic resonance imaging Lysine Isocyanate Polyurethane Phosphate Biomaterial
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Bioengineering Biomedical Engineering Polymers and Plastics

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Preparation and rapid degradation of nontoxic biodegradable polyurethanes based on poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid) and l-lysine diisocyanate

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