NDLI: Iodine-containing radio-opaque polyphosphazenes

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Polymer Chemistry Vol - 1 Issue - 8

Polymer Chemistry Vol - 1 Issue - 7

Polymer Chemistry Vol - 1 Issue - 6

Polymer Chemistry Vol - 1 Issue - 5

Polymer Chemistry Vol - 1 Issue - 4

Polymer Chemistry Vol - 1 Issue - 3

Polymer Chemistry Vol - 1 Issue - 2

Iodine-containing radio-opaque polyphosphazenes

Content Provider	Royal Society of Chemistry (RSC)
Author	Nair, Lakshmi S. Allcock, Harry R. Imler, Gregory H. Soudakov, Anton A. Laurencin, Cato T. Hindenlang, Mark D.
Copyright Year	2010
Abstract	The first poly(organophosphazenes) with iodinated side groups for possible use as radio-opaque biomaterials are reported. Depending on the types of side groups present, these polymers may be biostable or bioerodible. Single-substituent polymers with 4-iodophenoxy or 4-iodophenylanaline ethyl ester units as the only side groups were prepared. Although a single-substituent polymer with 3,5-diiodotyrosine ethyl ester groups was difficult to synthesize, probably because of steric hindrance, mixed-substituent polymers that contained the non-iodinated ethyl esters of glycine, alanine, or phenylalanine plus a corresponding iodinated substituent could be synthesized. 31P, 1H, and 13C NMR spectroscopy techniques were used to follow the linkage of the side groups to the phosphazene skeleton and to establish the ratios of the different side groups. Hydrolysis of the iodo-amino acid/non-iodinated amino acid side group species in deionized water at 37 °C followed a bulk hydrolysis profile, with the rates dependent on the structure of the side groups. The effectiveness of these polymers as X-ray opaque materials was examined by the use of the poly(organophosphazenes) and conventional organic polymers as filters for copper Kα or rhenium–tungsten–molybdenum radiation. The phosphazene polymers that contained iodine in the side groups were opaque to X-rays, whereas the conventional organic polymers were essentially transparent to the same radiation.
Starting Page	1467
Ending Page	1474
Page Count	8
File Format	HTM / HTML PDF
ISSN	17599954
Volume Number	1
Issue Number	9
Journal	Polymer Chemistry
DOI	10.1039/c0py00126k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Alanine Phenylalanine Polymer Steric effects Substituent Glycine Carbon-13 nuclear magnetic resonance Phosphazene Hydrolysis X-ray crystallography Ester Carboxylic acid Biomaterial Diiodotyrosine Copper Purified water Iodine
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Bioengineering Biomedical Engineering Polymers and Plastics

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