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Chitosan oligosaccharide copolymer micelles with double disulphide linkage in the backbone associated by H-bonding duplexes for targeted intracellular drug delivery

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Back cover

Polymer Chemistry Vol - 6 Issue - 8

Polymer Chemistry Vol - 6 Issue - 7

Polymer Chemistry Vol - 6 Issue - 6

Polymer Chemistry Vol - 6 Issue - 5

Polymer Chemistry Vol -5

Polymer Chemistry Vol -4

Polymer Chemistry Vol -3

Polymer Chemistry Vol -2

Polymer Chemistry Vol -1

Chitosan oligosaccharide copolymer micelles with double disulphide linkage in the backbone associated by H-bonding duplexes for targeted intracellular drug delivery

Content Provider	Royal Society of Chemistry (RSC)
Author	Gong, Bing Shen, Yu-Mei Shao, Zhifeng Yang, Qinglai Liu, Bingya Hou, Yongtai He, Changyu Zhu, Zhenggang Xu, Yuhong
Copyright Year	2015
Abstract	A folic acid (FA) conjugated chitosan oligosaccharide (CSO) polylactic acid (PLA) copolymer FA-CSO-PLA with double disulphide linkage in the backbone directed by H-bonding association duplex was synthesized, and its self-assembled micelles were evaluated as smart targeted drug delivery carriers. Both of the intermediates and the terminal copolymers were characterized by 1H-NMR and gel permeation chromatography (GPC). The critical micelle concentration (CMC) value is 0.045 mg mL−1 which suggests the micelles are highly stable in dilute solution. TEM and DLS further confirmed the successful formation of micelles with an average size of 61 and 100 nm, PDI of 0.209 and 0.230 for blank and DOX loaded micelles, respectively. The micelles were destructed under a reductive environment, leading to encapsulated drug release. Moreover, fluorescence microscopy demonstrated that the micelles exhibited both a passive and active targeting ability in HeLA cells due to an EPR effect and folate-mediated endocytosis. These results suggested the micelles would provide a favourable platform for constructing excellent drug delivery systems for cancer therapy.
Starting Page	1454
Ending Page	1464
Page Count	11
File Format	HTM / HTML PDF
ISSN	17599954
Volume Number	6
Issue Number	9
Journal	Polymer Chemistry
DOI	10.1039/c4py01473a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	PLA EPR Oligosaccharide Drug delivery Fluorescence microscope Gel permeation chromatography HeLA HeLa Endocytosis Critical micelle concentration Transmission electron microscopy PDI Dynamic light scattering CMC Chitosan Copolymer CSO Cancer
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Bioengineering Biomedical Engineering Polymers and Plastics

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