NDLI: A biocompatible cross-linked fluorescent polymer prepared via ring-opening PEGylation of 4-arm PEG-amine, itaconic anhydride, and an AIE monomer

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A biocompatible cross-linked fluorescent polymer prepared via ring-opening PEGylation of 4-arm PEG-amine, itaconic anhydride, and an AIE monomer

Content Provider	Royal Society of Chemistry (RSC)
Author	Zhang, Xiqi Wang, Ke Zhang, Xiaoyong Wei, Yen Liu, Hongliang Ma, Chunping Zhou, Yahong
Copyright Year	2015
Abstract	A novel cross-linked fluorescent polymer (PhE-ITA-PEG) was prepared through radical polymerization between an aggregation-induced emission (AIE) monomer and itaconic anhydride, and subsequent ring-opening PEGylation with 4-arm PEG-amine. The resulting fluorescent polymer could self-assemble to form polymeric nanoparticles in aqueous solution with hydrophilic PEG groups covered at the surfaces and the hydrophobic AIE components aggregated into the cores. The successful synthesis of the obtained PhE-ITA-PEG copolymer was fully characterized and confirmed by a series of techniques including gel permeation chromatography, 1H NMR spectroscopy, FT-IR spectroscopy, and X-ray photoelectron spectroscopy. Meanwhile, transmission electron microscopy and dynamic light scattering have been carried out to determine the morphology and distribution of these polymeric nanoparticles. UV-visible absorption spectra and fluorescence spectra have also been investigated to study their optical performances. Finally, biocompatibility and cell uptake behaviour of the PhE-ITA-PEG nanoparticles were further evaluated to explore their potential biomedical applications. The results demonstrated that PhE-ITA-PEG could self-assemble to form uniform spherical nanoparticles with diameters ranging from 50 to 80 nm and showed high water dispersibility, intense yellow fluorescence quantum yield (38%) and excellent biocompatibility, which made them promising candidates for cell imaging. More importantly, the strategy of facile ring-opening PEGylation of 4-arm PEG-amine, itaconic anhydride, and an AIE monomer in this work will provide a new path to prepare more novel biocompatible AIE-based cross-linked fluorescent polymers, and would expand the range of their bio-applications.
Starting Page	3634
Ending Page	3640
Page Count	7
File Format	HTM / HTML PDF
ISSN	17599954
Volume Number	6
Issue Number	19
Journal	Polymer Chemistry
DOI	10.1039/c5py00111k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Spectroscopy Radical polymerization Fluorescence Polymer Hydrophobe Fourier-transform infrared spectroscopy Photoemission spectroscopy Organic acid anhydride Gel permeation chromatography Quantum PEGylation Transmission electron microscopy Dynamic light scattering Biocompatibility Hydrophile Copolymer Nuclear magnetic resonance Monomer AIE X-ray photoelectron spectroscopy
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Bioengineering Biomedical Engineering Polymers and Plastics

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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