NDLI: Optimising the enzyme response of a porous silicon photonic crystal via the modular design of enzyme sensitive polymers

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Optimising the enzyme response of a porous silicon photonic crystal via the modular design of enzyme sensitive polymers

Content Provider	Royal Society of Chemistry (RSC)
Author	Soeriyadi, Alexander H. Gooding, J. Justin Gupta, Bakul Reece, Peter J.
Copyright Year	2014
Abstract	We describe the immobilization within the pores of a porous silicon photonic crystal of an enzyme degradable polymer network, for optical biosensing. A porous silicon (PSi) rugate filter is a one-dimensional photonic crystal with a high-reflectivity optical resonance that is sensitive to small changes in the refractive index of the pore space permeating through the structure. An enzymatically degradable polymer network was constructed by first “clicking” an antifouling copolymer, poly(oligo ethylene glycol-co-acrylic acid)-N3, to an alkyne functionalized PSi surface via copper(I)-catalysed alkyne–azide cycloaddition (CuAAC) reaction. MMP-2 or MMP-9 specific cleavable peptide sequences, with diamine functional groups, were then added, using a 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide/N-hydroxysuccinimide (EDC/NHS) chemistry to react with the acrylic acid group. The polymer network was completed by further attachment of a sacrificial polymer, poly(hydroxyethyl acrylate-co-N-hydroxysuccinimide ester acrylate). X-ray photoelectron spectroscopy (XPS) and optical reflectivity measurements reveal successful modification of the PSi with the polymer–peptide network. Exposure of the biosensor platform to solutions of matrix metalloproteinases, MMP-2 or MMP-9, caused a change in the average refractive index of the photonic crystal, resulting in a discernible blue shift in the reflectivity spectra. The blue shift indicated the degradation of the polymer network within the porous network. Selective detection of different MMPs was demonstrated, via the use of different peptide sequences, which are selectively digestible by different MMPs, to link the two polymers.
Starting Page	2333
Ending Page	2341
Page Count	9
File Format	HTM / HTML PDF
ISSN	17599954
Volume Number	5
Issue Number	7
Journal	Polymer Chemistry
DOI	10.1039/c3py01638b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Acrylic acid Ethylene Ester Carboxylic acid Extracellular matrix Oligonucleotide Nuclear magnetic resonance Copolymer Copper Peptide X-ray photoelectron spectroscopy Enzyme Polymer N-Hydroxysuccinimide Photoemission spectroscopy MMP9 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Diamine Organic chemistry Cycloaddition Blueshift Photonic crystal Biosensor Silicon photonics Alkyne
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Bioengineering Biomedical Engineering Polymers and Plastics

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