NDLI: Micelles with surface conjugated RGD peptide and crosslinked polyurea core via RAFT polymerization

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Micelles with surface conjugated RGD peptide and crosslinked polyurea core via RAFT polymerization

Content Provider	Royal Society of Chemistry (RSC)
Author	Duong, Hien T. T. Nguyen, T. L. Uyen Stenzel, Martina H.
Copyright Year	2010
Abstract	An improved drug delivery system was developed, which enhances the cellular uptake by stabilizing the micelle via core crosslinking resulting in the formation of stable core–shell particles and by decorating the micelles with arginine-glycine-aspartic acid (RGD) containing peptides. In order to generate stable core–shell nanoparticles, block copolymers composed of poly(oligo(ethylene glycol) methyl ether methacrylate)-block-polystyrene-co-poly(3-isopropenyl-α,α-dimethylbenzyl isocyanate) (POEGMA-block-P(STY-co-TMI)) were synthesized viareversible addition fragmentation chain transfer (RAFT) polymerization. Depending on the length of the hydrophobic block, self-assembled aggregates such as micelles, rods and large compound micelles were created in the aqueous solutions. The use of a protected aldehyde containing RAFT agent (CTA) allowed the formation of endfunctional block copolymers, producing micelles bearing aldehyde groups incorporated onto the surface allowing further conjugation with a RGD containing peptide after deprotection. The micelles were stabilized by core crosslinking through the reaction of reactive isocyanate groups with hexamethylenediamine forming stable urea containing core–shell particles. Conjugation with a RGD containing linear peptide, GRGDS, resulted in the formation of micelles bearing peptide groups on the surface. Cytotoxicity tests confirmed the biocompatibility of the synthesized crosslinked micelles revealing efficient cell uptake without causing any signs of cell damage. The conjugation of GRGDS to polymeric micelles and the core crosslinking was shown to significantly enhance the cellular uptake.
Starting Page	171
Ending Page	182
Page Count	12
File Format	HTM / HTML PDF
ISSN	17599954
Volume Number	1
Issue Number	2
Journal	Polymer Chemistry
DOI	10.1039/b9py00210c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Ethylene glycol Ether Micelle Polymerization Cytotoxicity Drug delivery Hydrophobe Hexamethylenediamine Oligomer Aldehyde List of Chicago Transit Authority bus routes CTA Urea Chain transfer Carboxylic acid Isocyanate Biocompatibility Peptide
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Bioengineering Biomedical Engineering Polymers and Plastics

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