NDLI: Dramatic selectivity differences in the association of DNA and RNA models with new ethylene- and propylene diamine derivatives and their copper complexes

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Organic & Biomolecular Chemistry Vol - 4 Issue - 8

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Organic & Biomolecular Chemistry Vol - 4 Issue - 6

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Dramatic selectivity differences in the association of DNA and RNA models with new ethylene- and propylene diamine derivatives and their copper complexes

Content Provider	Royal Society of Chemistry (RSC)
Author	Albelda, M. Teresa Lomadze, Nino Schneider, Hans-Jörg Verdejo, Begoña García-España, Enrique
Copyright Year	2006
Abstract	The affinities of polyamines consisting of ethylenediamine units equipped with either one or two terminal naphthyl-, anthryl-, or acridyl units towards PolyA.PolyU as an RNA model, and Poly(dA).Poly(dT) as a DNA model are screened by measuring the melting point changes (ΔTm) of the double strands, and also partially by a fluorimetric binding assay using ethidium bromide. The larger aromatic moieties with long spacers between them allow bisintercalation; this leads to an increased preference for DNA in comparison to RNA, where ion pairing of the ammonium centers with the major RNA groove phosphates dominates. Allosteric affinity control by metalation is achieved e.g. with Cu2+ ions, which induce conformational distortions within the chains. With anthryl- in contrast to naphthyl derivatives intercalation can be so strong that distortion of the ethylenediamine chain by metalation is not powerful enough. A particularly high concentration of positive charges is accessible with tripodal derivatives built up from ethylenediamine and propylenediamine units; in the absence of aryl parts, which interfere with the RNA groove preference, one observes the highest affinity difference known until today, reflected in a melting point ratio of ΔTm(RNA)/ΔTm(DNA) = 40, whereas other synthetic ligands reach only a ΔTm(RNA)/ΔTm(DNA) ratio of about 3.
Starting Page	1755
Ending Page	1759
Page Count	5
File Format	HTM / HTML PDF
ISSN	14770520
Volume Number	4
Issue Number	9
Journal	Organic & Biomolecular Chemistry
DOI	10.1039/b517386h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Ethylenediamine Ammonium Ethidium bromide RNA Aromaticity DNA Ion
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Physical and Theoretical Chemistry

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