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Back matter

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Organic & Biomolecular Chemistry Vol - 4 Issue - 6

Organic & Biomolecular Chemistry Vol - 4 Issue - 5

Organic & Biomolecular Chemistry Vol - 4 Issue - 4

Organic & Biomolecular Chemistry Vol - 4 Issue - 3

Organic & Biomolecular Chemistry Vol -3

Organic & Biomolecular Chemistry Vol -2

Synthesis and biological activity of tetralone abscisic acid analogues

Content Provider	Royal Society of Chemistry (RSC)
Author	Rose, Patricia A. Nyangulu, James M. Nelson, Ken M. Gai, Yuanzhu Lougheed, Brenda Quail, J. Wilson Cutler, Adrian J. Abrams, Suzanne R. Loewen, Mary
Copyright Year	2006
Abstract	Bicyclic analogues of the plant hormone abscisic acid (ABA) were designed to incorporate the structural elements and functional groups of the parent molecule that are required for biological activity. The resulting tetralone analogues were predicted to have enhanced biological activity in plants, in part because oxidized products would not cyclize to forms corresponding to the inactive catabolite phaseic acid. The tetralone analogues were synthesized in seven steps from 1-tetralone and a range of analogues were accessible through a second route starting with 2-methyl-1-naphthol. Tetralone ABA 8 was found to have greater activity than ABA in two bioassays. The absolute configuration of (+)-8 was established by X-ray crystallography of a RAMP hydrazone derivative. The hydroxymethyl compounds 10 and 11, analogues for studying the roles of 8′- and 9′-hydroxy ABA 3 and 6, were also synthesized and found to be active.
Starting Page	1400
Ending Page	1412
Page Count	13
File Format	HTM / HTML PDF
ISSN	14770520
Volume Number	4
Issue Number	7
Journal	Organic & Biomolecular Chemistry
DOI	10.1039/b509193d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	ABA Hormone X-ray crystallography 1-Naphthol Carboxylic acid Absolute configuration Eight foot pitch Hydrazone Tetralone
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Physical and Theoretical Chemistry

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A briefly overview of the research progress for the abscisic acid analogues

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Synthesis and biological activity of tetralone abscisic acid analogues

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