NDLI: Beyond carbohydrate binding: new directions in plant lectin research

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Back matter

Back cover

Organic & Biomolecular Chemistry Vol - 4 Issue - 5

Organic & Biomolecular Chemistry Vol - 4 Issue - 4

Organic & Biomolecular Chemistry Vol - 4 Issue - 3

Organic & Biomolecular Chemistry Vol -3

Organic & Biomolecular Chemistry Vol -2

Beyond carbohydrate binding: new directions in plant lectin research

Content Provider	Royal Society of Chemistry (RSC)
Author	Kavitha, Mannem Komath, Sneha Sudha Swamy, Musti J.
Copyright Year	2006
Abstract	Although for a long time carbohydrate binding property has been used as the defining feature of lectins, studies carried out mostly during the last two decades or so demonstrate that many plant lectins exhibit specific interactions with small molecules that are predominantly hydrophobic in nature. Such interactions, in most cases, appear to be at specific sites that do not interfere with the ability of the lectins to recognise and bind carbohydrates. Further, several of these ligands have binding affinities comparable to those for the binding of specific carbohydrates to the lectins. Given the ability of lectins to specifically recognise the glycocode (carbohydrate code) on different cell surfaces and distinguish between diseased and normal tissues, these additional sites may be viewed as potential drug carrying sites that could be exploited for targeted delivery to sites of choice. Porphyrin–lectin complexes are especially suited for such targeting since porphyrins are already under investigation in photodynamic therapy for cancer. This review will provide an update on the interactions of plant lectins with non-carbohydrate ligands, with particular emphasis on porphyrin ligands. The implications and potential applications of such studies will also be discussed.
Starting Page	973
Ending Page	988
Page Count	16
File Format	HTM / HTML PDF
ISSN	14770520
Volume Number	4
Issue Number	6
Journal	Organic & Biomolecular Chemistry
DOI	10.1039/b515446d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Photodynamic therapy Porphyrin Carbohydrate Hydrophobe Cancer
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Physical and Theoretical Chemistry

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Beyond carbohydrate binding: new directions in plant lectin research

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