NDLI: Light-driven conformational regulation of human telomeric G-quadruplex DNA in physiological conditions

Please wait, while we are loading the content...

Continuous-flow, palladium-catalysed alkoxycarbonylation reactions using a prototype reactor in which it is possible to load gas and heat simultaneously

2-Oxabutane as a substitute for internal monomer units of oligosaccharides to create lectin ligands

CuAAC synthesis of resorcin[4]arene-based glycoclusters as multivalent ligands of lectins

Emission control by binary energy transfer processes on oligouridine

γ-AApeptides bind to RNA by mimicking RNA-binding proteins

Self-assembling dipeptide-based nontoxic vesicles as carriers for drugs and other biologically important molecules

Understanding the cooperative NHC/LA catalysis for stereoselective annulation reactions with homoenolates. A DFT study

Synthetic polyion-counterion transport systems in polymersomes and gels

Syntheses of mGluR5 PET radioligands through the radiofluorination of diaryliodonium tosylates

Light-driven conformational regulation of human telomeric G-quadruplex DNA in physiological conditions

Preparation and characterisation of an equatorial para-adduct of (PhCH₂)HC₇₀ from the reaction of C₇₀²⁻ with benzyl bromide and H₂O: addition effects in the polar and equatorial regions of C₇₀

The synthesis of novel heteroaryl-fused 7,8,9,10-tetrahydro-6H-azepino[1,2-a]indoles, 4-oxo-2,3-dihydro-1H-[1,4]diazepino[1,7-a]indoles and 1,2,4,5-tetrahydro-[1,4]oxazepino[4,5-a]indoles. Effective inhibitors of HCV NS5B polymerase

Control of chemoselectivity in Dieckmann ring closures leading to tetramic acids

Synthesis of apiose-containing oligosaccharide fragments of the plant cell wall: fragments of rhamnogalacturonan-II side chains A and B, and apiogalacturonan

Nucleophilicity parameters for amines, amino acids and peptides in water. Variations in selectivities for quinone methides

Asymmetric additive-free aryl addition to aldehydes using perhydrobenzoxazines as ligands and boroxins as aryl source

First synthesis of an aziridinyl fused pyrrolo[1,2-a]benzimidazole and toxicity evaluation towards normal and breast cancer cell lines

Bifunctional phosphine-catalyzed cross-Rauhut–Currier/Michael/aldol condensation triple domino reaction: synthesis of functionalized cyclohexenes

N-Heterocyclic carbene-catalyzed aza-Michael addition

Highly diastereoselective vinylogous Mukaiyama aldol reaction of α-keto phosphonates with 2-(trimethylsilyloxy)furan catalyzed by Cu(OTf)₂

Regioselective ω-hydroxylation of medium-chain n-alkanes and primary alcohols by CYP153 enzymes from Mycobacterium marinum and Polaromonas sp. strain JS666

Enantioselective Morita–Baylis–Hillman reaction promoted by l-threonine-derived phosphine–thiourea catalysts

Unprecedented intramolecular [3 + 2] cycloadditions of azido-ketenimines and azido-carbodiimides. Synthesis of indolo[1,2-a]quinazolines and tetrazolo[5,1-b]quinazolines

Inverse electron-demand 1,3-dipolar cycloaddition of nitrile oxide with common nitriles leading to 3-functionalized 1,2,4-oxadiazoles

Pseudoceramines A–D, new antibacterial bromotyrosine alkaloids from the marine sponge Pseudoceratina sp.

A new general approach for the stereocontrolled synthesis of functionalised γ- and δ-lactams

Thermal reaction of [3,4]-benzo-8-substituted-3Z,5Z,7E-octatetraenes and quantum-chemical study of the (8π,6π)-electrocyclisation

Reactions of dehydrodiferulates with ammonia

Synthesis of mono- and di-[12]aneN₃ ligands and study on the catalytic cleavage of RNA model 2-hydroxypropyl-p-nitrophenyl phosphate with their metal complexes

Synthesis and configuration of the nonadecenetriol isolated from seeds of Persea americana

Efficient preparation of Fmoc-aminoacyl-N-ethylcysteine unit, a key device for the synthesis of peptide thioesters

Synthesis of the C19 methyl ether of aspercyclide A via germyl-Stille macrocyclisation and ELISA evaluation of both enantiomers following optical resolution

Development of highly stereoselective GalN₃ donors and their application in the chemical synthesis of precursors of Tn antigen

Efficient and versatile COMU-mediated solid-phase submonomer synthesis of arylopeptoids (oligomeric N-substituted aminomethyl benzamides)

Direct enantioselective access to 4-substituted tetrahydroquinolines by catalytic asymmetric transfer hydrogenation of quinolines

Back cover

Organic & Biomolecular Chemistry Vol - 9 Issue - 9

Organic & Biomolecular Chemistry Vol - 9 Issue - 8

Organic & Biomolecular Chemistry Vol - 9 Issue - 7

Organic & Biomolecular Chemistry Vol - 9 Issue - 6

Organic & Biomolecular Chemistry Vol - 9 Issue - 5

Organic & Biomolecular Chemistry Vol - 9 Issue - 4

Organic & Biomolecular Chemistry Vol - 9 Issue - 3

Organic & Biomolecular Chemistry Vol -8

Organic & Biomolecular Chemistry Vol -7

Organic & Biomolecular Chemistry Vol -6

Organic & Biomolecular Chemistry Vol -5

Organic & Biomolecular Chemistry Vol -4

Organic & Biomolecular Chemistry Vol -3

Organic & Biomolecular Chemistry Vol -2

Light-driven conformational regulation of human telomeric G-quadruplex DNA in physiological conditions

Content Provider	Royal Society of Chemistry (RSC)
Author	Zheng, Xiaolong Xu, Liang Dai, Luyang Mao, Wuxiang Xing, Xiwen Tai, Yang Xu, Xiaowei Wang, Xiaoling Zhou, Xiang
Copyright Year	2011
Abstract	Human telomeric G-quadruplexes have raised broad interest not just due to their involvement in the regulation of gene expressions and telomerase activities but also because of their application in nanoarchitectures. Herein, three azobenzene derivatives 1–3 were synthesized with different substituent groups and their photo-isomerization properties were investigated by UV/Vis spectroscopy. Then circular dichroism spectroscopy (CD), fluorescence experiments and native-gel electrophoresis were performed to evaluate their capabilities of conformational photo-regulation both in the absence and presence of metal ions. The results suggested that the compounds synthesized can successfully regulate the conformation of human telomeric G-quadruplex DNA in K+ conditions to some extent. This work will initiate the possibility for the design and intriguing application of light-induced switching to photoregulate the conformation of G-quadruplex DNA under physiological conditions, providing a possible pathway to control G-quadruplex conformation in biological applications and also expanding the potential use of G-quadruplexes in nanomachines.
Starting Page	6639
Ending Page	6645
Page Count	7
File Format	HTM / HTML PDF
ISSN	14770520
Volume Number	9
Issue Number	19
Journal	Organic & Biomolecular Chemistry
DOI	10.1039/c1ob05939d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Absorption spectroscopy Gene DNA G-quadruplex Fluorescence Conformational isomerism Electrophoresis Substituent Telomerase Azobenzene Circular dichroism
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Physical and Theoretical Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Ruthenium(ii) polypyridyl complexes as G-quadruplex inducing and stabilizing ligands in telomeric DNA

Chiral Metallo–Supramolecular Complexes Selectively Induce Human Telomeric G-Quadruplex Formation under Salt-Deficient Conditions

Promoting the formation and stabilization of human telomeric G-quadruplex DNA, inhibition of telomerase and cytotoxicity by phenanthroline derivatives

Stability of Human Telomeric G-Quadruplexes Complexed with Photosensitive Ligands and Irradiated with Visible Light.

Myricetin arrests human telomeric G-quadruplex structure: a new mechanistic approach as an anticancer agent

Orienting Tetramolecular G-Quadruplex Formation: The Quest for the Elusive RNA Antiparallel Quadruplex

Disubstituted 2-phenyl-benzopyranopyrimidine derivatives as a new type of highly selective ligands for telomeric G-quadruplex DNA

IR circular dichroism of turns in small peptides

Human replication protein A unfolds telomeric G-quadruplexes (2006)

Light-driven conformational regulation of human telomeric G-quadruplex DNA in physiological conditions

Similar Documents

Ruthenium(ii) polypyridyl complexes as G-quadruplex inducing and stabilizing ligands in telomeric DNA

Chiral Metallo–Supramolecular Complexes Selectively Induce Human Telomeric G-Quadruplex Formation under Salt-Deficient Conditions

Promoting the formation and stabilization of human telomeric G-quadruplex DNA, inhibition of telomerase and cytotoxicity by phenanthroline derivatives

Stability of Human Telomeric G-Quadruplexes Complexed with Photosensitive Ligands and Irradiated with Visible Light.

Myricetin arrests human telomeric G-quadruplex structure: a new mechanistic approach as an anticancer agent

Orienting Tetramolecular G-Quadruplex Formation: The Quest for the Elusive RNA Antiparallel Quadruplex

Disubstituted 2-phenyl-benzopyranopyrimidine derivatives as a new type of highly selective ligands for telomeric G-quadruplex DNA

IR circular dichroism of turns in small peptides

Human replication protein A unfolds telomeric G-quadruplexes (2006)

Light-driven conformational regulation of human telomeric G-quadruplex DNA in physiological conditions