NDLI: Supramolecular hydrogels based on short peptides linked with conformational switch

Content Provider	Royal Society of Chemistry (RSC)
Author	Lin, Hongkun Xu, Yanmei Shi, Junfeng Zhang, Yan Qiu, Zhenjun Huang, Yucheng
Copyright Year	2011
Abstract	Short peptides appropriately linked with an azobenzene conformational switch were found to be motif and pH dependant supramolecular hydrogelators. The hydrogelation properties of the short peptides linked with the conformational switch were studied in detail with respect to dependence on amino acid residue, pH and salt effect. The presence of amino acids with aromatic side chains such as Phe and Tyr was found to be favorable for the short peptides to gel water at an appropriate pH range. Cationic amino acid residues such as Arg and Lys in the short peptides were found to be unfavorable for hydrogelation. pH and salt effect were also found to be important factors for the hydrogelation properties of the short peptides. A series of short peptides with bioactive sequences were linked with the conformational switch and their hydrogelation properties were investigated. Photoresponsive supramolecular hydrogels were realized based on the E-/Z- transition of the conformational switch upon light irradiation. Proper combination of amino acid residues in the short peptides resulted in smart supramolecular hydrogels with responses to multiple stimuli.
Starting Page	2149
Ending Page	2155
Page Count	7
File Format	HTM / HTML PDF
ISSN	14770520
Volume Number	9
Issue Number	7
Journal	Organic & Biomolecular Chemistry
DOI	10.1039/c0ob01057j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Tyrosine Dependent and independent variables Carboxylic acid Lysine Lys PH Tyr Azobenzene
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry Physical and Theoretical Chemistry

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